Hsp90: the vulnerable chaperone.

Chiosis G; Vilenchik M; Kim J; Solit D

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Hsp90: the vulnerable chaperone.

机译：Hsp90：易受攻击的伴侣。

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The molecular chaperone Hsp90 has emerged as an important target in cancer treatment because of its roles in maintaining transformation and regulating the function of proteins involved in apoptotic, survival and growth pathways. Many Hsp90 inhibitors function by binding to the N-terminal ATP pocket, but the chaperone has many other vulnerable points. Agents that interact with its C-terminus or modify its post-translational status represent additional ways of interfering with chaperone activity. This review will discuss several emerging classes of Hsp90 inhibitors and their modes of action.

机译：分子伴侣蛋白Hsp90已经成为癌症治疗中的重要靶标，因为它在维持转化和调节凋亡，存活和生长途径中涉及的蛋白质功能中的作用。许多Hsp90抑制剂通过与N末端ATP口袋结合而起作用，但该伴侣分子还有许多其他脆弱点。与C末端相互作用或修饰其翻译后状态的试剂代表了干扰伴侣活性的其他方法。这篇综述将讨论Hsp90抑制剂的几种新兴类别及其作用方式。

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《Drug discovery today》 |2004年第20期|共8页
作者
Chiosis G; Vilenchik M; Kim J; Solit D;
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正文语种 eng
中图分类药学;
关键词
inhibitors; physiological aspects; Carbon ion; Review Publication Type;

机译：抑制剂生理方面碳离子综述[出版物类型];

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1. Hsp90: the vulnerable chaperone. [J] . Chiosis G, Vilenchik M, Kim J, Drug discovery today . 2004,第20期

机译：Hsp90：易受攻击的伴侣。
2. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. [J] . Kung PP, Sinnema PJ, Richardson P, Bioorganic and Medicinal Chemistry Letters . 2011,第12期

机译：针对应用于Hsp90分子伴侣的晶体学水的设计策略。
3. Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. [J] . Kung PP, Sinnema PJ, Richardson P, Bioorganic and Medicinal Chemistry Letters . 2011,第12期

机译：针对应用于Hsp90分子伴侣的晶体学水的设计策略。
4. UTILIZING ECTOPIC HSP90 EXPRESSION TO DIAGNOSE BREAST CANCER AT THE POINT-OF-CARE USING FLUORESCENCE MICROSCOPY [C] . Roujia Wang, Brian Crouch, Christopher Lam, Conference on advances in optics for biotechnology, medicine and surgery . 2019

机译：利用荧光显微技术利用ESPPIC表达的HSP90在护理点诊断乳腺癌
5. Regulation of Akt expression and signaling by the Hsp90 chaperone. [D] . Basso, Andrea Dawn. 2003

机译：Hsp90伴侣蛋白对Akt表达和信号传导的调节。
6. HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer [O] . Haitang Yang, Shun-Qing Liang, Duo Xu, 2019

机译：HSP90 / AXL / eIF4E调控的未折叠蛋白反应是耐药性KRAS突变型肺癌中的获得性脆弱性
7. Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone. [O] . Gabrielle Stetz, Amanda Tse, Gennady M Verkhivker 2017

机译：基于集合的建模和变构相互作用网络的刚性分解和细胞周期蛋白依赖性激酶的通信途径：区分Hsp90-Cdc37伴侣的激酶客户。
8. Creation of a Mouse with Stress-Induced Dystonia: Control of an ATPase Chaperone. [R] . Sweadner, K. J. 2013

机译：创建具有应激诱导的肌张力障碍的小鼠：控制aTp酶伴侣。

Hsp90: the vulnerable chaperone.

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