Application of statistical 'design of experiments' methods in drug discovery.

Tye H

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Application of statistical 'design of experiments' methods in drug discovery.

机译：统计“实验设计”方法在药物发现中的应用。

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The use of 'design of experiments' (DoE) is a revolutionary approach to optimisation and screening of experimental parameters. Simple experimental designs and statistical tools for data analysis can provide much information about the system under investigation after only a few experiments. Such information can be key in decision-making for further experiments and can enable the development of robust and reliable protocols for chemical synthesis, analytical methods or biological assays. Coupling of design of experiments with modern high-throughput automation systems has the potential to maximise the capabilities of these systems and give increased productivity for many drug discovery applications.

机译：“实验设计”（DoE）的使用是一种用于优化和筛选实验参数的革命性方法。简单的实验设计和用于数据分析的统计工具可以在仅进行几次实验后就提供有关所研究系统的大量信息。此类信息对于进一步实验的决策至关重要，并且可以为化学合成，分析方法或生物学分析开发健壮而可靠的协议。将实验设计与现代高通量自动化系统相结合，有可能使这些系统的功能最大化，并为许多药物发现应用提供更高的生产率。

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《Drug discovery today》 |2004年第11期|共7页
作者
Tye H;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
drug discovery; statistical; Application; NOS; experiment;

机译：药物发现;统计;应用;NOS;实验;

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1. Application of statistical 'design of experiments' methods in drug discovery. [J] . Tye H Drug discovery today . 2004,第11期

机译：统计“实验设计”方法在药物发现中的应用。
2. Uncommon applications of statistical methods of the design of experiments in chemical technology and environment protection [J] . Lewandowski, Grzegorz, ?wirko, Polish journal of chemical technology . 2007,第4期

机译：统计方法在化学技术和环境保护实验设计中的罕见应用
3. A hybrid statistical approach for modeling and optimization of RON: A comparative study and combined application of response surface methodology (RSM) and artificial neural network (ANN) based on design of experiment (DOE) [J] . Elfghi F. M. Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers . 2016,第Sepa期

机译：RON建模和优化的混合统计方法：基于实验设计（DOE）的响应面方法（RSM）和人工神经网络（ANN）的对比研究和组合应用
4. SOME APPLICATIONS OF STATISTICAL DESIGN OF EXPERIMENT METHODOLOGY IN CIVIL ENGINEERING [C] . L. M. Lye Annual conference of the Canadian Society for Civil Engineering;Conference of the Canadian Society for Civil Engineering;Congres annuel de la Societe Canadienne de Genie Civil;CSCE2003 . 2003

机译：实验方法的统计设计在土木工程中的一些应用
5. Bioinformatics, computational chemistry and structural biology: Development and application of methods to drug design and discovery. [D] . Ramanathan, Chandra Sekar. 1996

机译：生物信息学，计算化学和结构生物学：药物设计和发现方法的开发和应用。
6. A Discussion of Statistical Methods for Design and Analysis of Microarray Experiments for Plant Scientists [O] . Dan Nettleton 2006

机译：植物科学家微阵列实验设计和分析的统计方法的讨论
7. Uncommon applications of statistical methods of the design of experiments in chemical technology and environment protection [O] . Grzegorz Lewandowski, Jan Ćwirko 2007

机译：化学技术与环境保护实验设计统计方法的罕见应用
8. The Application of Statistical Methods to the Design and Analysis of Experiments [R] . Stoller, D. S. 1955

机译：统计方法在实验设计与分析中的应用

Application of statistical 'design of experiments' methods in drug discovery.

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