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首页> 外文期刊>Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology >Proteomics and its applications to aquaculture in China: Infection, immunity, and interaction of aquaculture hosts with pathogens
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Proteomics and its applications to aquaculture in China: Infection, immunity, and interaction of aquaculture hosts with pathogens

机译：蛋白质组学及其在中国水产养殖中的应用：水产养殖宿主与病原体的感染，免疫和相互作用

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摘要

China is the largest fishery producer worldwide in term of its aquaculture output, and plays leading and decisive roles in international aquaculture development. To improve aquaculture output further and promote aquaculture business development, infectious diseases and immunity of fishes and other aquaculture species must be studied. In this regard, aquaculture proteomics has been widely carried out in China to get a better understanding of aquaculture host immunity and microbial pathogenesis as well as host– pathogen interactions, and to identify novel disease targets and vaccine candidates for therapeutic interventions. These proteomics studies include development of novel methods, assays, and advanced concepts in order to characterize proteomics mechanisms of host innate immune defense and microbial pathogenesis. This review article summarizes some recently published technical approaches and their applications to aquaculture proteomics with an emphasis on the responses of aquaculture animals to bacteria, viruses, and other aqua-environmental stresses, and development of broadly cross-protective vaccine candidates. The reviewed articles are those that have been published in international peer reviewed journals.
机译：就水产养殖产量而言，中国是全球最大的渔业生产国，在国际水产养殖发展中起着领导和决定性的作用。为了进一步提高水产养殖产量并促进水产养殖业发展，必须研究传染病和鱼类及其他水产养殖物种的免疫力。在这方面，中国广泛开展了水产养殖蛋白质组学研究，以更好地了解水产养殖宿主的免疫力和微生物发病机理以及宿主与病原体的相互作用，并确定新的疾病靶标和候选疫苗进行治疗。这些蛋白质组学研究包括开发新方法，测定方法和先进概念，以表征宿主固有免疫防御和微生物发病机理的蛋白质组学机制。这篇综述文章总结了一些最近发表的技术方法及其在水产蛋白质组学中的应用，重点是水产动物对细菌，病毒和其他水环境压力的反应，以及广泛的交叉保护性疫苗的开发。审阅的文章是在国际同行审阅期刊上发表的文章。

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