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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Risk of breast cancer and breast cancer characteristics in women after treatment for Hodgkin lymphoma.
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Risk of breast cancer and breast cancer characteristics in women after treatment for Hodgkin lymphoma.

机译：霍奇金淋巴瘤治疗后女性患乳腺癌的风险和乳腺癌特征。

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摘要

Radiotherapy is important in the treatment of Hodgkin lymphoma. Although the risk of recurrent Hodgkin lymphoma decreases in long-term survivors, the incidence of radiation-induced cancers increases with time. Breast cancer is the main long-term concern for women. Risk factors associated with breast cancer development include age at irradiation, time since treatment and radiation dose received. The risk of developing breast cancer appears to be limited to women treated before age 30 years. The median time to breast cancer after radiotherapy is 15 years. Higher radiation doses are associated with higher risks. While the histology of breast cancers occurring after treatment for Hodgkin lymphoma appears similar to that of spontaneously occurring breast cancers, the age at diagnosis in these women is significantly younger, often at an age before regular breast screening is implemented. In this article, we review findings from retrospective studies on Hodgkin lymphoma and breast cancer including the risk factors, breast cancer characteristics, breast cancer management and options for primary and secondary prevention. The treatment goals for young female patients with Hodgkin lymphoma include: 1) manipulation of radiation dose and fields without compromising the outcome of the primary malignancy; 2) possible reversible manipulation of hormonal status without permanent effects on fertility; and 3) development of nonsurgical options for primary prevention of radiation-induced breast cancers. Carefully designed studies addressing these strategies and their interplay are needed.
机译：放射疗法对霍奇金淋巴瘤的治疗很重要。尽管长期幸存者复发霍奇金淋巴瘤的风险降低，但放射诱发的癌症的发生率随时间增加。乳腺癌是妇女长期关注的主要问题。与乳腺癌发展相关的危险因素包括放疗时的年龄，治疗后的时间和接受的放射剂量。患乳腺癌的风险似乎仅限于30岁之前接受治疗的女性。放射治疗后乳腺癌的中位时间为15年。更高的辐射剂量会带来更高的风险。尽管霍奇金淋巴瘤治疗后发生的乳腺癌的组织学看起来与自发性乳腺癌相似，但这些妇女的诊断年龄要年轻得多，通常是在进行常规乳房筛查之前。在本文中，我们回顾了有关霍奇金淋巴瘤和乳腺癌的回顾性研究结果，包括危险因素，乳腺癌特征，乳腺癌管理以及一级和二级预防的选择。年轻的霍奇金淋巴瘤女性患者的治疗目标包括：1）在不影响原发恶性肿瘤结果的情况下控制放射剂量和视野。 2）可能对激素状态进行可逆的操作而对生育力没有永久性影响; 3）开发非手术方法，以初步预防辐射诱发的乳腺癌。需要针对这些策略及其相互作用进行精心设计的研究。

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