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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >Dutasteride: A potent dual inhibitor of 5-alpha-reductase for benign prostatic hyperplasia.
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Dutasteride: A potent dual inhibitor of 5-alpha-reductase for benign prostatic hyperplasia.

机译：度他雄胺：一种有效的5-α-还原酶双重抑制剂，用于良性前列腺增生。

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摘要

Dutasteride is a 5alpha-reductase inhibitor that inhibits both types 1 and 2 isozymes of 5alpha-reductase, the enzyme responsible for converting testosterone to dihydrotestosterone in the prostate and other tissues. Dihydrotestosterone is the primary cause of prostate growth and has been proven to play a key role in the development and progression of benign prostatic hyperplasia. Dutasteride has been investigated in three multicenter studies involving 4325 men aged 50 years and above with benign prostatic hyperplasia. Data from these two-year, placebo-controlled studies demonstrated that dutasteride 0.5 mg once daily reduced the risk of both acute urinary retention and the need for benign prostatic hyperplasia-related surgical intervention, improved benign prostatic hyperplasia-related symptoms, decreased prostate volume and increased maximum urinary flow rates with a low incidence of generally mild to moderate adverse events. (c) 2004 Prous Science. All rights reserved.
机译：度他雄胺是一种5α-还原酶抑制剂，可抑制5α-还原酶的1型和2型同工酶，该酶负责在前列腺和其他组织中将睾丸激素转化为二氢睾丸激素。二氢睾丸激素是前列腺生长的主要原因，并且已被证明在良性前列腺增生的发生和发展中起关键作用。已在三项多中心研究中对度他雄胺进行了研究，涉及4325名50岁及以上的男性前列腺增生症。这些为期两年的安慰剂对照研究的数据表明，每日一次0.5 mg度他雄胺降低了急性尿retention留的风险和对良性前列腺增生相关的手术干预的需要，改善了良性前列腺增生相关的症状，降低了前列腺体积和最大尿流率增加，一般轻度至中度不良事件发生率低。 （c）2004 Prous科学。版权所有。

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