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CAPC changes heartworm guidelines due to evidence of resistance

机译：CAPC由于抗药性证据而改变了丝虫指南

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The Companion Animal Parasite Council (CAPC) has altered its guidelines after evidence of preventive-resistant Diofilaria immitis strains was presented at the American Association of Veterinary Parasitologists Conference at the end of July in Chicago.Researchers have now identified heartworm isolates from the Mississippi Delta region that develop in adult dogs receiving routine monthly heartworm preventives. At the conference, a number of parasitologists—including Byron Blagburn, PhD, of Auburn University, Dwight Bowman, PhD, of Cornell, and others—presented the findings of investigations funded by Novartis Animal Health, which has contributed $1.6 million to date toward studying resistance. "Resistance has been demonstrated across the macrocyclic lactone (ML) product class," writes Bowman in an introduction to a collection of the research abstracts. "All currently approved products have failed to prevent heartworm development in dogs when tested in experimentally induced infection models with Mississippi River Valley isolates." These products include ivermectin, selamectin, milbemycin oxime and moxidectin.
机译：伴随动物寄生虫委员会（CAPC）在7月底在芝加哥举行的美国兽医寄生虫学家协会会议上提出了预防耐药的双丝线虫免疫球菌菌株的证据后，对指南进行了更改，研究人员现已鉴定出密西西比河三角洲地区的心丝虫分离株在接受常规每月一次心丝虫预防剂的成年犬身上会出现这种情况。在会议上，包括奥本大学的Byron Blagburn博士，康奈尔大学的Dwight Bowman博士等在内的许多寄生虫学者介绍了由诺华动物卫生基金会资助的调查结果，该研究迄今已为研究贡献了160万美元抵抗性。 Bowman在介绍研究摘要的序言中写道：“已经证明了在大环内酯（ML）产品类别中的耐药性。” “在密西西比河谷分离株的实验性感染模型中进行测试时，目前所有已获批准的产品均未能阻止狗中的心丝虫发展。”这些产品包括伊维菌素，Selamectin，milbemycin肟和moxidectin。

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