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首页> 外文期刊>Drug and Chemical Toxicology >Effect of Organophosphorus and Organochlorine Pesticides (Monochrotophos,Chlorpyriphos,Dimethoate,and Endosulfan)on Human Lymphocytes In-Vitro
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Effect of Organophosphorus and Organochlorine Pesticides (Monochrotophos,Chlorpyriphos,Dimethoate,and Endosulfan)on Human Lymphocytes In-Vitro

机译：有机磷和有机氯农药（单环虫，毒死pho，灭草菊和硫丹）对人淋巴细胞的体外影响

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The toxicological profile of the four pesticides described herein characterizes its effects on lymphocytes from peripheral blood from healthy donors.The exposure to all pesticides was by direct interaction/incubation with varying concentrations of the pesticide with blood sample in-vitro.The dose response relationship in each case was calculated by applying log tables as LC_(50)values.Cytotoxicity of these pesticides on lymphocytes was measured using the trypan blue dye exclusion technique.Based on LC_(50)value,all the four pesticides were found to be highly toxic to lymphocyte culture,among them,monocrotophos and endo-sulfan were the most toxic and dimethoate was the least toxic.The genotoxicity of the pesticides was also determined by comet assay.The results revealed that the pesticides caused increase in the tail length indicating DNA damage.This study suggests that these pesticides have the capacity to alter the genetic material particularly chromosomes in mammalian cultures.The comet assay used in this study was found to be a sensitive and rapid method to detect genotoxicity of pesticide compounds.
机译：本文所述的四种农药的毒理学特征表征了其对健康供体外周血淋巴细胞的影响。所有农药的暴露是通过与不同浓度的农药与体外血样直接相互作用/温育进行的。每例均以对数表作为LC_（50）值进行计算。使用锥虫蓝染料排除技术测量这些农药对淋巴细胞的细胞毒性。基于LC_（50）值，发现所有四种农药对淋巴细胞培养中，久效磷和硫丹的毒性最高，乐果的毒性最低。还通过彗星分析法测定了农药的遗传毒性。结果表明，农药引起的尾巴长度增加表明DNA受损。这项研究表明，这些农药具有改变遗传物质的能力，尤其是哺乳动物文化中的染色体。这项研究中使用的met分析法是检测农药化合物遗传毒性的灵敏且快速的方法。

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