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首页> 外文期刊>Drug and alcohol dependence >Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats.
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Social reward-conditioned place preference: A model revealing an interaction between cocaine and social context rewards in rats.

机译：社会奖励条件的场所偏好：揭示可卡因与大鼠社会情境奖励之间相互作用的模型。

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摘要

A recent thrust in drug abuse research is the influence of social interactions on drug effects. Therefore, the present study examined conditioned place preference (CPP) as a model for assessing interactions between drug and social rewards in adolescent rats. Parameters for establishing social reward-CPP were examined, including the number of conditioning sessions/day (1 or 2), the total number of sessions (2, 8, or 16), and the duration of sessions (10 or 30min). Subsequently, the effects of cocaine or dextromethorphan on social reward-CPP and play behavior were examined. The results demonstrate that social reward-CPP (i.e., preference shift for an environment paired previously with a rat) was similar using either 1 or 2 conditioning sessions/day and either 10 or 30min sessions; however, social reward-CPP increased as the number of social pairings increased. Additionally, a low dose of cocaine (2mg/kg, IP) and a low number of social pairings (2 pairings) failed to produce CPP when examined alone, but together produced a robust CPP, demonstrating an interaction between these rewards. The non-rewarding drug, dextromethorphan (30mg/kg, IP), failed to enhance social reward-CPP, suggesting that drug-enhanced social reward-CPP is specific to rewarding drugs. Surprisingly, there was no relationship between play behaviors and preference shift in drug-naive animals. Furthermore, cocaine inhibited play behavior despite enhancing social reward-CPP, suggesting that aspects of social interaction other than play behavior likely contribute to social reward. The findings have important implications for understanding the influence of social context on cocaine reward during adolescence.
机译：药物滥用研究的最新重点是社交互动对药物作用的影响。因此，本研究研究了条件场所偏爱（CPP）作为评估青春期大鼠药物与社会奖励之间相互作用的模型。检查了建立社会奖励CPP的参数，包括每天的适应性会话数（1或2），会话总数（2、8或16）以及会话持续时间（10或30分钟）。随后，研究了可卡因或右美沙芬对社交奖励CPP和游戏行为的影响。结果表明，每天使用1或2个条件训练课程或每天10或30分钟的会话，社交奖励CPP（即先前与大鼠配对的环境的偏好转移）相似;但是，随着社交配对数量的增加，社交奖励CPP也随之增加。此外，当单独检查时，低剂量的可卡因（2mg / kg，IP）和少量的社交配对（2个配对）不能产生CPP，但是一起产生了强大的CPP，表明了这些奖励之间的相互作用。非奖励药物右美沙芬（30mg / kg，IP）未能增强社会奖励CPP，这表明药物增强的社会奖励CPP专门针对奖励药物。令人惊讶的是，在未吸毒的动物中游戏行为与偏好改变之间没有关系。此外，可卡因尽管增强了社会奖励CPP，但仍抑制了游戏行为，这表明除了游戏行为以外的社交互动方面也可能有助于社会奖励。这些发现对理解社会环境对可卡因奖励在青春期的影响具有重要意义。

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