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首页> 外文期刊>Addiction biology >Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats.
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Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats.

机译：通过社交互动在大鼠中逆转可卡因调节的位置偏好和中皮质糖皮质Zif268表达。

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摘要

Little is known how social interaction, if offered as an alternative to drug consumption, affects neural circuits involved in drug reinforcement and substance dependence. Conditioned place preference (CPP) for cocaine (15 mg/kg i.p.) or social interaction (15 minutes) as an alternative stimulus was investigated in male Sprague-Dawley rats. Four social interaction episodes with a male adult conspecific completely reversed cocaine CPP and were even able to prevent reacquisition of cocaine CPP. Social interaction also reversed cocaine CPP-induced expression of the immediate-early gene zif268 in the nucleus accumbens shell, the central and basolateral amygdala and the ventral tegmental area. These findings suggest that social interaction, if offered in a context that is clearly distinct from the previously drug-associated ones, may profoundly decrease the incentive salience of drug-associated contextual stimuli. The novel experimental design facilitates the neurobiological investigation of this phenomenon which may be beneficial for human drug users in treatment.
机译：人们几乎不知道社交互动如何作为药物消费的替代品，如何影响参与药物强化和物质依赖的神经回路。在雄性Sprague-Dawley大鼠中研究了可卡因（15 mg / kg i.p.）的条件性位置偏好（CPP）或社交互动（15分钟）作为替代刺激。男性成年同种型的四个社交互动事件完全逆转了可卡因CPP，甚至能够阻止可卡因CPP的重新获得。社会交往也逆转了可卡因CPP诱导的伏伏核壳，中央和基底外侧杏仁核以及腹侧被盖区域中即早基因zif268的表达。这些发现表明，如果在明显不同于先前与药物相关的环境中提供社交互动，则可能会大大降低与药物相关的环境刺激的激励显着性。新颖的实验设计有助于对该现象的神经生物学研究，这可能对人类吸毒者的治疗有益。

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