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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele.
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Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele.

机译：超过15年的西班牙HIV-1感染长期非进展者CX3CR1 249I变异等位基因的频率增加。

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摘要

BACKGROUND AND OBJECTIVES: The influence of the polymorphisms of the CX3CR1 chemokine receptor gene on the natural history of HIV-1 infection is controversial. This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients. PATIENTS AND METHODS: Two single-nucleotide polymorphisms, V249I (G > A) and T280M (C > T), of the CX3CR1 gene were assessed in 271 Spaniards. These included 60 HIV-1-infected patients who were long-term nonprogressors (LTNPs) of >15 years, 109 HIV-1-infected patients who were usual progressors (UPs), and 102 control subjects. The CCR5Delta32 was also assessed. Genotyping was performed using polymerase chain reaction and automatic sequencing analysis methods on white cell DNA. Genotype and allele frequencies were compared by the chi test and the Fisher exact test. RESULTS: The frequencies of the 249I variant allele were 42% for LTNPs, 24.5% for UPs, and 35% for healthy controls; the differences between LTNPs and UPs were significant (odds ratio 0.46; 95% CI: 0.27 to 0.75; P = 0.0017). For 280M the distribution was 16% for LTNPs, 14% for UPs, and 17% for healthy controls (P = NS). The haplotype 249I280T was significantly more common in LTNPs than in UPs (P = 0.0007). These results persisted after excluding from the analysis the individuals carrying the CCR5Delta32. CONCLUSIONS: CX3CR1 249I variant allele is more frequent in Spanish HIV-1-infected LTNPs of >15 years. This effect is independent of the presence of the CCR5Delta32 allele.
机译：背景与目的：CX3CR1趋化因子受体基因多态性对HIV-1感染自然史的影响尚存争议。这项研究旨在确定在西班牙HIV-1感染的患者中，功能活跃的CX3CR1基因变异是否与> 15年的长期非进行性感染相关。患者和方法：在271个西班牙人中评估了CX3CR1基因的两个单核苷酸多态性，即V249I（G> A）和T280M（C> T）。其中包括60例长期未进展（LTNP）≥15年的HIV-1感染患者，109例通常进展（UPs）的HIV-1感染患者和102例对照对象。还评估了CCR5Delta32。使用聚合酶链反应和自动测序分析方法对白细胞DNA进行基因分型。基因型和等位基因频率通过卡氏检验和费舍尔精确检验进行比较。结果：249I变异等位基因的频率为LTNPs为42％，UPs为24.5％，健康对照者为35％。 LTNPs和UPs之间的差异非常显着（赔率比为0.46; 95％CI：0.27至0.75; P = 0.0017）。对于280M，LTNP的分布为16％，UPs的分布为14％，健康对照组的分布为17％（P = NS）。单倍型249I280T在LTNP中比在UPs中更为常见（P = 0.0007）。从分析中排除携带CCR5Delta32的个体后，这些结果仍然存在。结论：CX3CR1 249I变异等位基因在西班牙HIV-1感染的LTNP中（> 15年）更为常见。此效应与CCR5Delta32等位基因的存在无关。

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