...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Lipodystrophy and metabolic disorders in HIV-1-infected adults on 4- to 9-year antiretroviral therapy in Senegal: a case-control study.
【24h】

Lipodystrophy and metabolic disorders in HIV-1-infected adults on 4- to 9-year antiretroviral therapy in Senegal: a case-control study.

机译：塞内加尔接受4至9年抗逆转录病毒治疗的HIV-1感染成人的脂肪营养不良和代谢紊乱：一项病例对照研究。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To assess adverse effects of long-term highly active antiretroviral therapy (HAART), that is, lipodystrophy and metabolic disorders, in a cohort of African patients. METHODS: One hundred eighty HIV-1-infected patients treated with HAART for 4-9 years in Dakar and 180 age-matched and sex-matched controls were enrolled. Regional subcutaneous fat changes were assessed by physicians, and fasting blood samples were drawn. Centralization of body fat was estimated using skinfold ratio, waist circumference, and waist to hip ratio (WHR). RESULTS: Mean duration of HAART was 5.4 years. Main drugs received were zidovudine, stavudine, and protease inhibitors. The prevalence of moderate-severe lipodystrophy was 31.1% (95% confidence interval: 24.3 to 37.9), with 13.3%, 14.5%, and 3.3% for lipoatrophy, lipohypertrophy, and mixed forms, respectively. Mild-severe lipodystrophy affected 65.0% (58.0; 72.0) of patients. Stavudine was the only independent risk factor (any vs. none: odds ratio = 2.8; 1.4 to 5.5). Patients had lower body mass index and skinfolds but greater centralization of body fat (WHR, P < 0.0001 and skinfold ratio, P < 0.001), fasting glucose (P < 0.0001), homeostasis model assessment insulin resistance, and triglyceride levels (P < 0.01 for both) than controls. Moderately-severely lipodystrophic patients had higher triglyceride and low-density lipoprotein cholesterol than other patients (P < 0.001 and P < 0.05, respectively). CONCLUSIONS: Moderate-severe lipodystrophy affected one third of West African patients on long-term HAART and was associated with a less favorable metabolic profile.
机译：目的：评估长期高活性抗逆转录病毒疗法（HAART）对一群非洲患者的不良反应，即脂肪营养不良和代谢异常。方法：入选180例在达喀尔接受HAART治疗4-9年的HIV-1感染患者，并纳入180个年龄匹配和性别匹配的对照组。由医生评估皮下脂肪的局部变化，并抽取空腹血样。使用皮褶比，腰围和腰臀比（WHR）估算体内脂肪的集中度。结果：HAART的平均持续时间为5。4年。接受的主要药物是齐多夫定，司他夫定和蛋白酶抑制剂。中度重度脂肪营养不良的患病率为31.1％（95％置信区间：24.3至37.9），脂肪营养不良，脂肪肥大和混合形式的患病率分别为13.3％，14.5％和3.3％。轻度重度脂肪营养不良影响了65.0％（58.0; 72.0）的患者。司他夫定是唯一的独立危险因素（任何与否：优势比= 2.8; 1.4至5.5）。患者的体重指数和皮肤褶皱较低，但体内脂肪的集中度较高（WHR，P <0.0001和皮肤褶皱比率，P <0.001），空腹血糖（P <0.0001），体内稳态模型评估的胰岛素抵抗和甘油三酸酯水平（P <0.01两者）。中重度脂肪营养不良患者的甘油三酸酯和低密度脂蛋白胆固醇水平高于其他患者（分别为P <0.001和P <0.05）。结论：中度至重度脂肪营养不良影响了长期使用HAART的三分之一西非患者，并伴有不良的代谢特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号