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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Plasma homocysteine is not associated with HIV serostatus or antiretroviral therapy in women.
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Plasma homocysteine is not associated with HIV serostatus or antiretroviral therapy in women.

机译：血浆同型半胱氨酸与女性的HIV血清状况或抗逆转录病毒疗法无关。

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BACKGROUND: The effects of HIV serostatus and combination antiretroviral therapy (cART) on plasma homocysteine (HCY) are uncertain. METHODS: Plasma HCY was assayed in a cross-sectional study of 249 HIV-infected and 127 HIV-uninfected women at the Bronx Women's Interagency HIV Study site. RESULTS: Mean plasma HCY was 7.42 +/- 2.68 in HIV-infected women and 7.18 +/- 2.66 mumol/L in HIV-uninfected women (P = 0.40). Hyperhomocysteinemia (defined as HCY >10 mumol/L) was seen in 16.9% and 13.4% of HIV-infected and HIV-uninfected women, respectively (P = 0.45). Among HIV-infected women, cART use was not associated with HCY level. Compared with the lowest quartile, women with HCY in the highest quartile had lower mean serum vitamin B12 and RBC folate levels. In multivariate analysis that did not include micronutrient levels, age, serum creatinine, and lower CD4% were significantly associated with plasma HCY level in HIV-infected women. CONCLUSIONS: Plasma HCY was not associated with HIV serostatus or use of cART in this cross-sectional study. Reduced availability of folate cofactors for HCY remethylation in HIV-infected women with lower folate intake and decreased health status may influence HCY levels.
机译：背景：HIV血清状态和联合抗逆转录病毒疗法（cART）对血浆同型半胱氨酸（HCY）的影响尚不确定。方法：在布朗克斯妇女机构间艾滋病研究中心对249名HIV感染妇女和127名HIV未感染妇女进行了一项横断面研究，测定了血浆HCY。结果：HIV感染妇女的平均血浆HCY为7.42 +/- 2.68，HIV未感染妇女的平均血浆HCY为7.18 +/- 2.66 mumol / L（P = 0.40）。高同型半胱氨酸血症（定义为HCY> 10μmol/ L）分别在感染HIV和未感染HIV的女性中分别占16.9％和13.4％（P = 0.45）。在感染艾滋病毒的妇女中，使用cART与HCY水平无关。与最低四分位数相比，在最高四分位数中患有HCY的妇女的平均血清维生素B12和RBC叶酸水平较低。在不包括微量营养素水平，年龄，血清肌酐和较低CD4％的多变量分析中，HIV感染妇女的血浆HCY水平显着相关。结论：该横断面研究中血浆HCY与HIV血清状况或使用cART无关。在叶酸摄入量较低且健康状况下降的HIV感染妇女中，用于HCY甲基化的叶酸辅助因子的可用性降低可能会影响HCY水平。

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