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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Impact of HIV-1 infection on the hematological recovery after clinical malaria.
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Impact of HIV-1 infection on the hematological recovery after clinical malaria.

机译：HIV-1感染对临床疟疾后血液学恢复的影响。

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BACKGROUND: Anemia is the most frequent cytopenia in HIV-infected individuals and is often associated with malaria. OBJECTIVE: To assess the impact of HIV-1 on the hematological recovery after a clinical malaria episode. METHODS: In Ndola, Zambia, a region with high malaria and HIV prevalence, hemoglobin (Hb) was measured in 634 malaria patients 14 and 45 days after antimalarial treatment. Risk factors for hematological recovery were analyzed in a multivariate linear regression model. RESULTS: At enrollment, HIV-1-infected malaria patients had lower Hb compared with HIV-1 uninfected (122.7 vs 136.0 g/L; P < 0.001). In both groups, mean Hb was significantly lower at day 14 posttreatment than day 0 (P < 0.0001) and significantly higher at day 45 than at day 14 (HIV-1 negative: P = 0.0001; HIV-1 infected: P = 0.005). HIV-1 was a risk factor for a larger Hb decrease until day 14 (P < 0.001) and slower recovery until day 45 (P = 0.048). When considering the whole 45-day follow-up period, mean Hb increased in the HIV-1-negative group (+3.54 g/L; 95% confidence interval: 1.37 to 5.70; P = 0.001) but not in the HIV-1-infected group (-0.72 g/L; 95% confidence interval: -3.85 to +2.40; P = 0.64). HIV-1 infection as such (P < 0.0001), not CD4 cell count (P = 0.46), was an independent risk factor for a slower hematological recovery. CONCLUSIONS: HIV-1-infected malaria patients had a slower hematological recovery after successful parasite clearance. Malaria preventive measures should be targeted to this high-risk group.
机译：背景：贫血是艾滋病毒感染者中最常见的血细胞减少症，通常与疟疾有关。目的：评估临床疟疾发作后HIV-1对血液恢复的影响。方法：在赞比亚恩多拉这个疟疾高发地区，在抗疟疾治疗后14天和45天对634名疟疾患者进行了血红蛋白（Hb）测定。在多元线性回归模型中分析了血液学恢复的危险因素。结果：入组时，感染HIV-1的疟疾患者的Hb低于未感染HIV-1（122.7 vs 136.0 g / L; P <0.001）。在两组中，治疗后第14天的平均Hb均显着低于第0天（P <0.0001），第45天的平均Hb显着高于第14天（HIV-1阴性：P = 0.0001; HIV-1感染：P = 0.005） 。 HIV-1是导致Hb降低直至第14天（P <0.001）且恢复较慢直到第45天（P = 0.048）的危险因素。考虑整个45天的随访期间，HIV-1阴性组的平均Hb升高（+3.54 g / L; 95％置信区间：1.37至5.70; P = 0.001），而HIV-1没有感染组（-0.72 g / L; 95％置信区间：-3.85至+2.40; P = 0.64）。像这样的HIV-1感染（P <0.0001），而不是CD4细胞计数（P = 0.46），是血液学恢复缓慢的独立危险因素。结论：成功清除寄生虫后，感染HIV-1的疟疾患者血液学恢复较慢。疟疾预防措施应针对这一高风险人群。

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