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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Surprisingly high prevalence of subtype C and specific HIV-1 subtype/CRF distribution in men having sex with men in Senegal.
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Surprisingly high prevalence of subtype C and specific HIV-1 subtype/CRF distribution in men having sex with men in Senegal.

机译：塞内加尔与男性发生性关系的男性中，亚型C的患病率和特定的HIV-1亚型/ CRF分布令人惊讶地高。

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BACKGROUND: Recent reports showed the high vulnerability for HIV infection of men who have sex with men (MSM) in Africa. Here, we report the HIV-1 variants that circulate among MSM in Senegal. METHODS: HIV-1 subtype/circulating recombinant form (CRF) was determined in an 1800-base pair fragment of pol for 70 HIV-1-positive samples from MSM. Phylogenetic trees were constructed using the neighbor-joining method with CLUSTALX. Similarity and bootstrap plots were then done for recombination analysis. The maximum likelihood approach was used for the identification of transmission clusters. RESULTS: Sixty-seven samples (95%) were from Senegalese MSM, 90% unmarried with a median age of 30 years. Fifty-five MSM had regular male partners, but 39 of 70 had also a regular female partner. The overall subtype/CRF distribution was as follows: 28 C (40%), 17 CRF02_AG (24.3%), 13 B (18.6%), 6 G (8.6%), 3 CRF09_cpx (4.3%), and 3 (4.3%) unique recombinants. In addition, 47 sequences (67.15%) were segregated into 15 transmission clusters. CONCLUSIONS: These variants circulate also among the general population or female sex workers, but the proportions are significantly different. Despite the massive stigma, the majority (80%) of MSM recognized having sex with women and could serve as a bridge for intermixing of HIV-1 variants between high-risk men and low-risk women.
机译：背景：最近的报道显示，非洲男性同性性行为（MSM）的男性很容易感染HIV。在这里，我们报告了在塞内加尔MSM中传播的HIV-1变异。方法：对70个来自MSM的HIV-1阳性样品，在pol的1800个碱基对片段中测定HIV-1亚型/循环重组形式（CRF）。系统发育树是使用CLUSTALX的邻居连接方法构建的。然后进行相似度和自举图的重组分析。最大似然方法用于识别传输集群。结果：67个样本（95％）来自塞内加尔MSM，90％未婚，中位年龄为30岁。五十五名男男性接触者有固定的男性伴侣，但70名中有39名也有固定的女性伴侣。总体亚型/ CRF分布如下：28 C（40％），17 CRF02_AG（24.3％），13 B（18.6％），6 G（8.6％），3 CRF09_cpx（4.3％）和3（4.3％） ）独特的重组体。另外，将47个序列（67.15％）分离为15个传输簇。结论：这些变异在普通人群或女性性工作者中也有传播，但比例差异很大。尽管存在很大的污名，MSM的大多数（80％）都承认与女性发生性关系，并可以充当高危男性和低危女性之间HIV-1变异体混合的桥梁。

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