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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Effects of different antigenic stimuli on thymic function and interleukin-7/CD127 system in patients with chronic HIV infection
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Effects of different antigenic stimuli on thymic function and interleukin-7/CD127 system in patients with chronic HIV infection

机译：不同抗原刺激对慢性HIV感染患者胸腺功能和白介素7 / CD127系统的影响

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BACKGROUND: We tested if an increase in immune activation and a decrease in CD4 T cells induced by different antigenic stimuli could be associated with changes in the thymic function and the interleukin (IL)-7/CD127 system. METHODS: Twenty-six HIV-infected patients under combined antiretroviral therapy (cART) were randomized to receive, during 12 months, a complete immunization schedule (7 vaccines and 15 doses) or placebo. Thereafter, cART was interrupted during 6 months. Changes in the thymic function and the IL-7/CD127 system after 3 different antigenic stimuli (vaccines, episodes of low-level intermittent viremia before cART interruption, or viral load rebound after cART interruption) were assessed. RESULTS: During the period on cART, neither vaccines nor low-level viremia influenced thymic function or IL-7/CD127 system parameters. By analyzing the cohort as a whole while on cART, a significant improvement was observed in the thymic function as measured by an increase in the thymic volume (P = 0.024), T-cell receptor excision circle-bearing cells (P = 0.012), and naive CD4 and CD8 T cells (P = 0.069 both). No significant changes were observed in the IL-7/CD127 system. After cART interruption, a decrease in T-cell receptor excision circles (P < 0.001) and naive CD8 T cells (P < 0.001), an increase in IL-7 and expression of CD127 on naive and memory CD4 T cells (P = 0.028, P = 0.088, and P = 0.04, respectively), and a significant decrease in CD127 on naive and memory CD8 T cells (P = 0.01, P = 0.006, respectively) were observed. CONCLUSIONS: Low-level transient antigenic stimuli during cART were not associated with changes in the thymic function or the IL-7/CD127 system. Conversely, viral load rebound very early after cART interruption influenced the thymic function and the IL-7/CD127 system. Clinical Trials.gov number NCT00329251.
机译：背景：我们测试了不同抗原刺激诱导的免疫激活增加和CD4 T细胞减少是否与胸腺功能和白介素（IL）-7 / CD127系统的改变有关。方法：26名接受抗逆转录病毒联合疗法（cART）感染HIV的患者在12个月内随机接受完整的免疫方案（7种疫苗和15剂）或安慰剂。此后，cART在6个月内中断。评估了3种不同的抗原刺激（疫苗，cART中断前低水平间歇病毒血症发作或cART中断后病毒载量反弹）后胸腺功能和IL-7 / CD127系统的变化。结果：在使用cART期间，疫苗和低水平病毒血症均不会影响胸腺功能或IL-7 / CD127系统参数。通过在cART上对整个队列进行分析，可以观察到胸腺功能的显着改善，如胸腺体积的增加（P = 0.024），T细胞受体切除的圆形细胞（P = 0.012），以及原始CD4和CD8 T细胞（均P = 0.069）。在IL-7 / CD127系统中未观察到明显变化。 cART中断后，T细胞受体切除环减少（P <0.001）和幼稚CD8 T细胞（P <0.001），IL-7的增加以及幼稚和记忆CD4 T细胞上CD127的表达（P = 0.028） ，分别为P = 0.088和P = 0.04），并且观察到幼稚和记忆CD8 T细胞上CD127的显着减少（分别为P = 0.01，P = 0.006）。结论：cART期间的低水平瞬时抗原刺激与胸腺功能或IL-7 / CD127系统的改变无关。相反，cART中断后病毒载量反弹很快，影响了胸腺功能和IL-7 / CD127系统。 Clinical Trials.gov编号NCT00329251。

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