Experimental design issue for assessment of carotenoids lutein and zeaxanthin in age-related eye disease study 2 formulation for age-related macular degeneration

BenkeK.K.; ChewE.Y.; BenkeK.E.; ClemonsT.E.

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Experimental design issue for assessment of carotenoids lutein and zeaxanthin in age-related eye disease study 2 formulation for age-related macular degeneration

机译：在年龄相关性眼病研究中评估类胡萝卜素叶黄素和玉米黄质的实验设计问题研究2年龄相关性黄斑变性的配方

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A recent assessment of the Age-Related Eye Disease Study 2 (AREDS2) trial of micronutrients for treatment of age-related macular degeneration (AMD) was very interesting, detailed, and insightful. One recommendation from the trial was to replace beta carotene in the supplement by the carotenoids lutein and zeaxanthin to minimize risk of lung cancer in smokers and ex-smokers. As observed by Musch, this was noteworthy for a clinical trial as it prompted recommendation for reformulation of the original AREDS supplement. A subsequent analysis of subgroups found improved confidence in recommending the replacement and revealed moderate improvements in risk reduction of AMD. One important issue deserves further comment and elaboration.

机译：最近一项有关微营养素治疗与年龄有关的黄斑变性（AMD）的年龄相关性眼病研究2（AREDS2）试验的最新评估非常有趣，详尽且有见地。该试验的一项建议是用类胡萝卜素叶黄素和玉米黄质代替补充物中的β-胡萝卜素，以最大程度地减少吸烟者和前吸烟者患肺癌的风险。正如Musch所观察到的那样，这对于临床试验是值得注意的，因为它促使人们建议重新配制原始AREDS补充剂。随后对亚组的分析发现，在推荐替代药物方面的信心得到了增强，并显示出AMD风险降低的适度改善。一个重要问题值得进一步评论和阐述。

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《JAMA ophthalmology》 |2014年第7期|共1页
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BenkeK.K.; ChewE.Y.; BenkeK.E.; ClemonsT.E.;
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1. Experimental design issue for assessment of carotenoids lutein and zeaxanthin in age-related eye disease study 2 formulation for age-related macular degeneration [J] . BenkeK.K., ChewE.Y., BenkeK.E., JAMA ophthalmology . 2014,第7期

机译：在年龄相关性眼病研究中评估类胡萝卜素叶黄素和玉米黄质的实验设计问题研究2年龄相关性黄斑变性的配方
2. Re: Van Asten et al.: No CFH/ARMS2 interaction with omega-3 fatty acids, low vs high zinc, or beta-carotene versus Lutein and Zeaxanthin on progression of age-related macular degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18 [J] . Zanke Brent, Kustra Rafal Ophthalmology . 2020,第3期

机译：Re：Van Asten等人：NO CFH / ARM2与Omega-3脂肪酸的相互作用，低于高锌，或β-胡萝卜素与叶黄素和Zeaxanthin在年龄相关眼病学习中的年龄相关性黄斑变性的进展情况2 ：年龄相关的眼病学习2号报告18
3. Re: Van Asten et al.: No CFH/ARMS2 interaction with omega-3 fatty acids, low vs high zinc, or beta-carotene versus Lutein and Zeaxanthin on progression of age-related macular degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18 REPLY [J] . van Asten Freekje, Chiu Chi-Yang, Agron Elvira, Ophthalmology . 2020,第3期

机译：Re：Van Asten等人：NO CFH / ARM2与Omega-3脂肪酸的相互作用，低于高锌，或β-胡萝卜素与叶黄素和Zeaxanthin在年龄相关眼病学习中的年龄相关性黄斑变性的进展情况2 ：年龄相关眼病研究2举报18号回复
4. Investigation of retinal microstructure in healthy eyes and dry age-related macular degeneration using a combined AO-OCT-SLO system [C] . Elaine M. Wells-Gray, Stacey S. Choi, Matthew Ohr, Ophthalmic technologies XXVII . 2017

机译：使用组合式AO-OCT-SLO系统研究健康眼睛的视网膜微结构和与干龄相关的黄斑变性
5. Relationships of body fat, retinal levels of lutein and zeaxanthin, and age-related maculopathy in the carotenoids in age-related eye disease study. [D] . Larowe, Tara Lea. 2005

机译：年龄相关性眼病研究中人体脂肪，叶黄素和玉米黄质的视网膜水平与类胡萝卜素中年龄相关性黄斑病变的关系。
6. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in Age-Related Eye Disease Study (CAREDS) an ancillary study of the Womens Health Initiative [O] . Suzen M. Moeller, Rick Voland, Lesley Tinker, -1

机译：老年性眼病研究（CAREDS）中妇女年龄相关性白内障与饮食中叶黄素和玉米黄质及类胡萝卜素血清之间的关联
7. Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS) [O] . Suzen M. Moeller 2006

机译：年龄相关性黄斑和叶黄素和玉米蛋黄和玉米蛋白和Zeaxanthin在年龄相关眼病学习中的联系（关心）

Experimental design issue for assessment of carotenoids lutein and zeaxanthin in age-related eye disease study 2 formulation for age-related macular degeneration

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