...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >PHENYL DERIVATED BUTYROLACTONES FROM THE FERMENTATION PRODUCTS OF AN ENDOPHYTIC FUNGUS ASPERGILLUS TERREUS
【24h】

PHENYL DERIVATED BUTYROLACTONES FROM THE FERMENTATION PRODUCTS OF AN ENDOPHYTIC FUNGUS ASPERGILLUS TERREUS

机译：内生真菌Aspergillus Terreus发酵产物中的苯甲酰化丁内酯

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two new phenyl derivated butyrolactones, terrephenols A and B (1 and 2), together with four known butyrolactones (3-6) were isolated from the fermentation products of a fungus Aspergillus terreus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1-6 were evaluated. Compounds 1 and 2 showed high anti-TMV activities with inhibition rates of 35.2% and 31.0 %, and 3-6 showed modest anti-TMV activity with inhibition rates of 15.4-24.6%, respectively. Compounds 1 and 2 were also tested for their cytotoxicities. 1 showed high cytotoxicity against A549 and MCF7 cell with IC_(50) values of 4.2 and 3.6 μM, and 2 showed high cytotoxicity against A549 and MCF7 cell with IC_(50) values of 3.9 and 4.8 μM, respectively.
机译：从真菌曲霉曲霉的发酵产物中分离出两个新的苯基衍生的丁内酯，对苯二酚A和B（1和2）以及四个已知的丁内酯（3-6）。通过光谱方法，包括广泛的1D-NMR和2D-NMR技术，阐明了它们的结构。评估了1-6的抗烟草花叶病毒（anti-TMV）活性。化合物1和2显示出高的抗TMV活性，抑制率分别为35.2％和31.0％，化合物3和6显示出适度的抗TMV活性，抑制率分别为15.4-24.6％。还测试了化合物1和2的细胞毒性。 1显示对A549和MCF7细胞的高细胞毒性，IC_（50）值为4.2和3.6μM，2显示对A549和MCF7细胞的高细胞毒性，IC_（50）值为3.9和4.8μM。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号