FACILE SYNTHSIS AND EVALUATION OF ANTITUMOR AND ANTIVIRAL ACTIVITIES OF[1,2,5]THIADIAZOLO[3,4-d]-PYRIMIDINES(8-THIAPURINES)AND 4-beta-D-RIBOFURANOSYL-[1,2,5]THIADIAZOLO[3,4-d]PYRIMIDINES

Tomohisa Nagamatsu; Rafiqul Islam; Noriyuki Ashida

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FACILE SYNTHSIS AND EVALUATION OF ANTITUMOR AND ANTIVIRAL ACTIVITIES OF[1,2,5]THIADIAZOLO[3,4-d]-PYRIMIDINES(8-THIAPURINES)AND 4-beta-D-RIBOFURANOSYL-[1,2,5]THIADIAZOLO[3,4-d]PYRIMIDINES

机译：[1,2,5]噻二唑[3,4-d]-嘧啶（8-噻啶）和4-β-D-呋喃核糖基-[1,2,5]噻二唑[1,2,5]噻吩的合成与抗和抗病毒活性的评价3,4-d]嘧啶

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Synthesis of 5-amino-[1,2,5]thiadiazoIo[3,4-d]pyrimidin-7(6H)-ones(8-thiaguanine)(4a-m),7-amino-[1,2,5]thiadiazolo[3,4-d]pyrirnidin-5(4H)-ones(8-thiaisoguanine)(6a-k),5,7-diamino-[1,2,5]thiadiazolo[3,4-d]pyrimidines(8a-d)and some other thiadiazolopyrimidine derivatives were prepared by treating 6-amino-5-nitrosopyrimidine derivatives with sodium thiosulfate in aqueous acid media.4-beta-D-Ribofuranosyl-[1,2,5]thiadiazolo[3,4-d]pyrimidine-5,7(4H,6H)-dione(8-thiaxanthosine)(18)was also prepared by the reliable method.Moderate antitumor and antiviral activities of the synthesized compounds have been evaluated in vitro.

机译：5-氨基-[1,2,5]噻二唑[3,4-d]嘧啶-7（6H）-一（8-硫鸟嘌呤）（4a-m），7-氨基-[1,2,5 ] thiadiazolo [3,4-d] pyridiridin-5（4H）-ones（8-thiaisoguanine）（6a-k），5,7-diamino- [1,2,5] thiadiazolo [3,4-d] pyrimidines （8a-d）和其他一些噻二唑并嘧啶衍生物是通过在水性酸性介质中用硫代硫酸钠处理6-氨基-5-亚硝基嘧啶衍生物而制得的。4-β-D-呋喃呋喃糖基-[1,2,5]噻二唑并[3,4]还通过可靠的方法制备了-d]嘧啶-5,7（4H，6H）-二酮（8-噻吨黄嘌呤）（18）。已在体外评价了所合成化合物的适度抗肿瘤和抗病毒活性。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第0期|共16页
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Tomohisa Nagamatsu; Rafiqul Islam; Noriyuki Ashida;
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1. FACILE SYNTHSIS AND EVALUATION OF ANTITUMOR AND ANTIVIRAL ACTIVITIES OF[1,2,5]THIADIAZOLO[3,4-d]-PYRIMIDINES(8-THIAPURINES)AND 4-beta-D-RIBOFURANOSYL-[1,2,5]THIADIAZOLO[3,4-d]PYRIMIDINES [J] . Tomohisa Nagamatsu, Rafiqul Islam, Noriyuki Ashida Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第0期

机译：[1,2,5]噻二唑[3,4-d]-嘧啶（8-噻啶）和4-β-D-呋喃核糖基-[1,2,5]噻二唑[1,2,5]噻吩的合成与抗和抗病毒活性的评价3,4-d]嘧啶
2. Bis(toluene)chromium(I) [1,2,5]Thiadiazolo[3,4-c][1,2,5]thiadiazolidyl and [1,2,5]Thiadiazolo[3,4-b]pyrazinidyl: New heterospin (S _1 = S _2 = 1/2) radical-ion salts [J] . Semenov N.A., Pushkarevsky N.A., Suturina E.A., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2013,第11期

机译：双（甲苯）铬（I）[1,2,5]噻二唑[3,4-c] [1,2,5]噻二唑基和[1,2,5]噻二唑[3,4-b]吡嗪基：新杂旋（S _1 = S _2 = 1/2）自由基离子盐
3. Synthesis of the 4,7-Dibromo Derivative of Highly Electron- Deficient [1,2,5]Thiadiazolo[3,4-d]pyridazine and Its Cross- Coupling Reactions [J] . Timofey N. Chmovzh, Ekaterina A. Knyazeva, Ludmila V. Mikhalchenko, European journal of organic chemistry . 2018,第41期

机译：合成高电子缺陷的4,7-二溴衍生物[1,2,5]噻二唑[3,4-D]哒嗪及其交叉偶联反应
4. Synthsis of 1,2,5thiadiazolo3,4-cpyridine: A Novel analogue to BT [C] . SUN Xiaoxia, LOU Yazhou, CHEN Qiangqiang, International Conference on Materials and Products Manufacturing Technology . 2011

机译：1,2,5噻二唑3,4-C吡啶的合成：新型与BT的类似物
5. Pyrimidine enzyme-specific activity at four different phases of growth in minimal and rich media, and concomitant evaluation of virulence factor production. [D] . Azad, Kamran Nikkhah. 2005

机译：嘧啶酶在最少和丰富培养基中四个不同生长阶段的比活性，以及对毒力因子生产的评估。
6. Ultrasound Mediated One-Pot Three Component Synthesis Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-88a-dihydro-7H-(134)thiadiazolo(32-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents [O] . Shailee V. Tiwari, Julio A. Seijas, M. Pilar Vazquez-Tato, 2016

机译：超声介导的新型5-氨基-2-（4-氯苯基）-7取代苯基-88a-二氢-7H-（134）噻二唑的一锅三组分合成对接和ADME预测32-α）嘧啶-6-腈衍生物作为抗癌药
7. Studies on pyrazolo(3,4-d)pyrimidine derivatives. XIII. Aryl migration of 4-aroyl-1H-pyrazolo(3,4-d)pyrimidines to 4-aryl-4,5-dihydro-1H-pyrazolo(3,4-d)pyrimidine-4-carboxylic acids. [O] . TAKEO HIGASHINO, YASUHIKO MATSUSHITA, MASUMI TAKEMOTO, 1983

机译：吡唑（3,4-D）嘧啶衍生物的研究。 XIII。 4-芳亚-1H-吡唑（3,4-D）嘧啶的芳基迁移至4-芳基-4,5-二氢-1H-吡唑（3,4-D）嘧啶-4-羧酸。

FACILE SYNTHSIS AND EVALUATION OF ANTITUMOR AND ANTIVIRAL ACTIVITIES OF[1,2,5]THIADIAZOLO[3,4-d]-PYRIMIDINES(8-THIAPURINES)AND 4-beta-D-RIBOFURANOSYL-[1,2,5]THIADIAZOLO[3,4-d]PYRIMIDINES

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