MULTICOMPONENT SYNTHESIS OF NOVEL 2- AND 3-SUBSTITUTED DIHYDROBENZO[1,4]OXAZEPINONES AND TETRAHYDRO-BENZO[1,4]DIAZEPIN-5-ONES AND THEIR CONFORMATIONAL ANALYSIS

Luca Banff; Andrea Basso; Giuseppe Guanti

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MULTICOMPONENT SYNTHESIS OF NOVEL 2- AND 3-SUBSTITUTED DIHYDROBENZO[1,4]OXAZEPINONES AND TETRAHYDRO-BENZO[1,4]DIAZEPIN-5-ONES AND THEIR CONFORMATIONAL ANALYSIS

机译：新型2和3取代的双羟基苯并[1,4]恶二烯酮和四羟基苯并[1,4]二氮杂-5-酮的多组分合成及其结构分析

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By coupling an Ugi multicomponent condensation with a Mitsunobu reaction,a series of 2- and 3-substituted dihydrobenzo[l,4]oxazepinones and tetrahydrobenzo[l,4]diazepin-5-ones was synthesized in a very convergent manner.The strategy involves the use of substituted ethanolamines as amino components and of salicylic or N-methanesulphonyl anthranilic acid as carboxylic component.The general scope has been evaluated;in some cases better results have been obtained by reverting the order of the two reactions.A thorough conformational analysis on these products has been carried out through NMR,showing that in most cases a single conformation was strongly favoured.

机译：通过将Ugi多组分缩合反应与Mitsunobu反应偶联，以非常收敛的方式合成了一系列2-和3-取代的二氢苯并[1,4]氧杂a酮和四氢苯并[1,4]二氮杂-5-酮。使用取代的乙醇胺作为氨基组分，水杨酸或N-甲磺酰基邻氨基苯甲酸作为羧酸组分。已评估了一般范围;在某些情况下，通过还原两个反应的顺序获得了更好的结果。这些产物已经通过NMR进行了分析，表明在大多数情况下，强烈支持单一构象。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第1期|共30页
作者
Luca Banff; Andrea Basso; Giuseppe Guanti;
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1. MULTICOMPONENT SYNTHESIS OF NOVEL 2- AND 3-SUBSTITUTED DIHYDROBENZO[1,4]OXAZEPINONES AND TETRAHYDRO-BENZO[1,4]DIAZEPIN-5-ONES AND THEIR CONFORMATIONAL ANALYSIS [J] . Luca Banff, Andrea Basso, Giuseppe Guanti Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第1期

机译：新型2和3取代的双羟基苯并[1,4]恶二烯酮和四羟基苯并[1,4]二氮杂-5-酮的多组分合成及其结构分析
2. Synthesis of novel 2,4-disubstituted 3H-pyrido[3,2-e][1,4]diazepin-5-ones and 2,4-disubstituted 3H-pyrido[2,3-e][1,4]diazepin-5-ones derivatives via regioselective thionation and nucleophilic substitutions reactions [J] . El Bouakher A., Prié G., Aadil M., Tetrahedron . 2013,第25期

机译：新型2,4-二取代的3H-吡啶并[3,2-e] [1,4]二氮杂五酮和2,4-二取代的3H-吡啶并[2,3-e] [1,4]二氮杂通过区域选择性硫磺化和亲核取代反应的-5-one衍生物
3. Synthesis of pyrazino[2,3-e][1,4]diazepin-5-one and pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin-5-one derivatives via the intramolecular aza-Witting reaction [J] . Okawa T., Eguchi S. Tetrahedron . 1998,第22期

机译：吡嗪并[2,3-e] [1,4]二氮杂五-5-酮和吡嗪并[2,3-e]吡咯并[1,2-a] [1,4]二氮杂-5-一衍生物的合成分子内氮杂-Witting反应
4. Microwave-Assisted One-Pot Multicomponent Synthesis of 1,4-Dihydropyridine Derivatives using Nanochitosan [C] . D. Febriantini, A. H. Cahyana, R. T. Yunarti, International Symposium on Current Progress in Mathematics and Sciences . 2019

机译：使用纳米分组的微波辅助1罐多组分合成1,4-二氢吡啶衍生物
5. Design and synthesis of novel scaffolds for drug discovery: Hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one and the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines. [D] . Abrous, Leila. 2001

机译：用于药物发现的新型支架的设计和合成：β-D-葡萄糖与1,2,3,4-四氢苯并[e] [1,4]二氮杂5-1-酮和相应的1-氧杂氮平以及2-和4-吡啶二氮杂卓。
6. 2-(1-Propyl-2,6-distyryl-1,4-dihydropyridin-4-ylidene)malononitrile [O] . Kwang Ha, Joon Heo, Hyung Jin Kim 2016

机译：2-（1-丙基-2,6-二苯乙烯-1,4-二氢吡啶-4-4-基亚乙基）丙二腈
7. Diphosphine-Catalyzed Mixed Double-Michael Reaction: A Unified Synthesis of Indolines, Dihydropyrrolopyridines, Benzimidazolines, Tetrahydroquinolines, Tetrahydroisoquinolines, Dihydrobenzo-1,4-oxazines, and Dihydrobenzo-3,1-oxazines [O] . Vardhineedi Sriramurthy, Ohyun Kwon 2010

机译：二膦催化混合双迈克尔反应：吲哚吲哚，二氢吡咯吡啶，苯并喹啉，四氢喹啉，四氢异喹啉，二氢苯并-1,4-唑胺和二氢苯-3,1-恶化的统一合成
8. Phase Transfer Pd(O) Catalyzed Polymerization Reactions. 1. Synthesis of 1,2-(4,4'-Dialkoxyaryl)Acetylene Monomers and 1,4-Bis(2-(4',4''-Dialkoxyphenyl)Ethynyl)Benzene Derivatives by Phase Transfer Pd(O)/Cu(I) Catalyzed Coupling Reactions. [R] . Pugh, C., Percec, V. 1990

机译：相转移pd（O）催化的聚合反应。 1.相转移pd（O）/ Cu合成1,2-（4,4'-二烷氧基芳基）乙炔单体和1,4-双（2-（4'，4'-二烷氧基苯基）乙炔基）苯衍生物（I）催化的偶联反应。

MULTICOMPONENT SYNTHESIS OF NOVEL 2- AND 3-SUBSTITUTED DIHYDROBENZO[1,4]OXAZEPINONES AND TETRAHYDRO-BENZO[1,4]DIAZEPIN-5-ONES AND THEIR CONFORMATIONAL ANALYSIS

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