SYNTHESIS OF THIENO(3,2-e)(l,2,4)TRIAZOLO(l,5-c)PYRIMIDIN-5(6fl)-ONES VIA THEIR (l,2,4)TRIAZOLO(4,3-c)PYRIMIDINE COMPOUNDS AS NEW RING SYSTEMS BY DIMROTH-TYPE REARRANGEMENT

Tomohisa Nagamatsu; Shoeb Ahmed; Abugafar M. L. Hossion; Seiji Ohno

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >SYNTHESIS OF THIENO(3,2-e)(l,2,4)TRIAZOLO(l,5-c)PYRIMIDIN-5(6fl)-ONES VIA THEIR (l,2,4)TRIAZOLO(4,3-c)PYRIMIDINE COMPOUNDS AS NEW RING SYSTEMS BY DIMROTH-TYPE REARRANGEMENT

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SYNTHESIS OF THIENO(3,2-e)(l,2,4)TRIAZOLO(l,5-c)PYRIMIDIN-5(6fl)-ONES VIA THEIR (l,2,4)TRIAZOLO(4,3-c)PYRIMIDINE COMPOUNDS AS NEW RING SYSTEMS BY DIMROTH-TYPE REARRANGEMENT

机译：硫代（3,2-e）（1,2,4）三唑（1,5-c）嘧啶-5（6fl）的合成（1,2,4）三唑（4,3-c）吡咯烷酮化合物通过消旋型重排作为新的环系统

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General and facile syntheses of thieno[3,2-el[l,2,4]triazolo[l,5-c]-pyrimidin-5(6H)-one (6a) and its 2-substituted derivatives (6b-j) produced by instantaneous isomerization of their [4,3-c] compounds (7a-j), which were prepared by condensation of 4-hydrazinothieno[2,3-d|pyrimidin-2(lH)-皀e (10) with appropriate triethyl orthoesters or by oxidative cyclization of 4-(benzylidenehydrazino)thieno[2,3-d]pyrimidin-2(lH)-ones (llc-j); are described as novel ring systems and as a new class of potential xanthine oxidase inhibitors. The [1,5-c] isomers (6a-c) were further prepared by condensation of 3-amino-4-imino-2-oxo-l,2,3,4-tetrahydrothieno|2,3-

机译：噻吩并[3,2-el [1,2,4]三唑并[1,5-c]-嘧啶-5（6H）-one（6a）及其2-取代衍生物（6b-j）的通用合成方法它们的[4,3-c]化合物（7a-j）瞬时异构化制备的产物，这些化合物是通过将4-肼基hi基[2,3-d |嘧啶-2（lH）-皀e（10）与适当的缩合反应制得原酸三乙酯或4-（苄叉肼基）噻吩并[2,3-d]嘧啶-2（1H）-ones（llc-j）的氧化环化;被称为新型环系统和一类潜在的黄嘌呤氧化酶抑制剂。 [1,5-c]异构体（6a-c）通过将3-氨基-4-亚氨基-2-亚氨基-2-氧代-1,2,3,4-四氢噻吩基| 2,3- <嘧啶（14）缩合而进一步制备）与适当的三乙基原酸酯作为一种可靠的三环系统结构的合成方法。

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来源
《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第1期|共17页
作者
Tomohisa Nagamatsu; Shoeb Ahmed; Abugafar M. L. Hossion; Seiji Ohno;
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正文语种 eng
中图分类杂环化合物;
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L; Physical condensation;

机译：L;物理凝结;

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1. SYNTHESIS OF THIENO(3,2-e)(l,2,4)TRIAZOLO(l,5-c)PYRIMIDIN-5(6fl)-ONES VIA THEIR (l,2,4)TRIAZOLO(4,3-c)PYRIMIDINE COMPOUNDS AS NEW RING SYSTEMS BY DIMROTH-TYPE REARRANGEMENT [J] . Tomohisa Nagamatsu, Shoeb Ahmed, Abugafar M. L. Hossion, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第1期

机译：硫代（3,2-e）（1,2,4）三唑（1,5-c）嘧啶-5（6fl）的合成（1,2,4）三唑（4,3-c）吡咯烷酮化合物通过消旋型重排作为新的环系统
2. Synthesis and rearrangements of 7H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]-and 7H-pyrrolo[3,2-e] [1,2,4]triazolo[4,3-c]pyrimidines [J] . E.V.Vorobev, E.S.Kurbatov, V.V.Krasnikov Russian Chemical Bulletin . 2006,第8期

机译：7H-吡咯并[3,2-e] [1,2,4]三唑[1,5-c]-和7H-吡咯并[3,2-e] [1,2,4]三唑[ 4,3-c]嘧啶
3. Synthesis of 8-Bromo-7-chloro[l,2,4]triazolo[4,3-c]pyrimidines, Their Ring Rearrangement to [1,5-c] Analogues, and Further Diversification [J] . Caifei Tang, Chao Wang, Zhiming Li, Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2014,第20期

机译：8-Bromo-7-氯[1,2,4]三唑并[4,3-c]嘧啶的合成，其环重排为[1,5-c]类似物和进一步多样化
4. Annellation of Triazole and Tetrazole Systems onto Pyrrolo23-dpyrimidines: Synthesis of Tetrazolo15-c-pyrrolo32-e-pyrimidines and Triazolo15-cpyrrolo-32-epyrimidines as Potential Antibacterial Agents [O] . Chaitanya G. Dave, Rina D. Shah 2002

机译：三唑和四唑体系在吡咯并23-d嘧啶上的退火反应：替他唑并15-c-吡咯并32-e-嘧啶和三唑并15-c吡咯并 32-e嘧啶类作为潜在的抗菌剂
5. Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents [O] . Rina D. Shah, Chaitanya G. Dave 2002

机译：将三唑和四唑体系连接到吡咯并[2,3-d]嘧啶上：四唑并[1,5-c] - 吡咯并[3,2-e] - 嘧啶和三唑并[1,5-c]吡咯并[]的合成3,2-e]嘧啶作为潜在的抗菌剂

SYNTHESIS OF THIENO(3,2-e)(l,2,4)TRIAZOLO(l,5-c)PYRIMIDIN-5(6fl)-ONES VIA THEIR (l,2,4)TRIAZOLO(4,3-c)PYRIMIDINE COMPOUNDS AS NEW RING SYSTEMS BY DIMROTH-TYPE REARRANGEMENT

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