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首页> 外文期刊>Japanese Journal of Ophthalmology >A prospective study of iridial pigmentation and eyelash changes due to ophthalmic treatment with latanoprost
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A prospective study of iridial pigmentation and eyelash changes due to ophthalmic treatment with latanoprost

机译：拉坦前列素眼科治疗引起的虹膜色素沉着和睫毛变化的前瞻性研究

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Purpose: To conduct a 12-month prospective study on the occurrence of latanoprost-induced iridial pigmentation and eyelash change in Japanese patients with glaucoma.Methods: Seventy-five patients (75 eyes) were enrolled in the study. Photographs of the iris and eyelashes were taken under identical conditions before and after treatment. Three glaucoma specialists assessed the iridial pigmentation/eyelash change independently with no knowledge of patient data. The effects of age, sex, concomitant medication, and type of glaucoma on iridial pigmentation/eyelash change were investigated, and intraocular pressure (IOP) reduction and iridocorneal angle pigmentation before and after latanoprost treatment were compared between patients with iridial pigmentation/eyelash change and patients without these changes.Results: The incidence of iridial pigmentation was 6.3% at 1 month, 15.7%, at 3 months, 37.8% at 6 months, and 56.5%, at 12 months. The incidence of eyelash change was 0% at 1 month, 33.8% at 3 months, 44.4% at 6 months, and 46.2% at 12 months. Latanoprost did not affect IOP reduction or iridocorneal angle pigmentation. No significant relationship between iridial pigmentation and eyelash change was observed. None of the investigated parameters except age affected the iridial pigmentation/eyelash change.Conclusion: Iridial pigmentation and eyelash change occurred at a high frequency in long-term treatment with latanoprost in Japanese glaucoma patients. (C) Japanese Ophthalmological Society 2004.
机译：目的：对日本青光眼患者中拉坦前列素引起的虹膜色素沉着和睫毛变化进行为期12个月的前瞻性研究。方法：纳入75例（75只眼）患者。在治疗前后，虹膜和睫毛的照片在相同的条件下拍摄。三名青光眼专家在不了解患者数据的情况下独立评估了虹膜色素沉着/睫毛的变化。研究了年龄，性别，伴随用药和青光眼类型对虹膜色素沉着/睫毛变化的影响，并比较了拉坦前列素治疗前后眼内压（IOP）降低和虹膜角膜角色素沉着的情况。结果：虹膜色素沉着的发生率在1个月时为6.3％，在3个月时为15.7％，在6个月时为37.8％，在12个月时为56.5％。睫毛改变的发生率在1个月时为0％，在3个月时为33.8％，在6个月时为44.4％，在12个月时为46.2％。拉坦前列素不影响眼压降低或虹膜角膜角色素沉着。虹膜色素沉着和睫毛变化之间没有显着关系。结论：在日本青光眼患者长期接受拉坦前列素的长期治疗中，虹膜色素沉着和睫毛变化的发生频率很高。 （C）日本眼科学会2004。

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