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首页> 外文期刊>Japanese Journal of Ophthalmology >Sialic Acid in human tear fluid decreases in dry eye.
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Sialic Acid in human tear fluid decreases in dry eye.

机译：人眼泪液中的唾液酸在干眼症中减少。

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PURPOSE: To evaluate the association between tear mucin and dry eye, we compared tear fluid sialic acid concentration in dry eye patients with that in normal volunteers. We also compared the sialic acid concentration with the results of several different types of dry eye examinations. METHODS: Subjects comprised 16 age-matched, normal healthy controls and 45 dry eye patients. Dry eye examinations included fluorescein staining, rose bengal staining, Schirmer I test, cotton thread test, and fluorescein breakup time. Tear samples were collected with a micropipette after the instillation of 50 microl saline. The sialic acid concentration was measured by high-performance liquid chromatography. RESULTS: The sialic acid concentration was significantly lower in the dry eye group (5.3 +/- 4.3 microg/ml) than in the control group (37.1 +/- 28.3 microg/ml) (P < 0.001). Also, the sialic acid concentration correlated significantly with the results of dry eye examinations (P < 0.0002). CONCLUSIONS: The different sialic acid levels in the control and dry eyes may imply differences in the quantity or quality of glycoprotein in tears between these two groups. Thus, sialic acid, a component of mucin, may play a key role in the dry eye condition.
机译：目的：为评估泪液粘蛋白与干眼症之间的关系，我们将干眼症患者的泪液唾液酸浓度与正常志愿者的泪液唾液酸浓度进行了比较。我们还将唾液酸浓度与几种不同类型的干眼检查的结果进行了比较。方法：受试者包括16名年龄匹配的正常健康对照者和45名干眼患者。干眼检查包括荧光素染色，玫瑰孟加拉染色，Schirmer I测试，棉线测试和荧光素分解时间。滴入50微升盐水后，用微量移液器收集眼泪样品。通过高效液相色谱法测定唾液酸浓度。结果：干眼组的唾液酸浓度（5.3 +/- 4.3微克/毫升）显着低于对照组（37.1 +/- 28.3微克/毫升）（P <0.001）。而且，唾液酸浓度与干眼检查结果显着相关（P <0.0002）。结论：对照组和干眼症中唾液酸水平的不同可能暗示着这两组之间泪液中糖蛋白的数量或质量存在差异。因此，唾液酸（粘蛋白的一种成分）可能在干眼症中起关键作用。

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