Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment.

Yamamoto S; Nagaki Y; Fukuo Y; Hirata H

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Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment.

机译：水合他克莫司（FK506）处理的光感受器跨物种移植。

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Photoreceptors from normal neonatal or transgenic neonatal mice with normally developing retinas were transplanted into the subretinal spaces of normal rats. The animals with transplants received either immunosuppressive treatment with tacrolimus hydrate for the first two weeks after transplantation or no treatment. At 4 weeks after transplantation, graft survival occurred only in rats treated with tacrolimus. In 7 of the 12 treated eyes, photoreceptors survived at least 4 weeks after transplantation. Relatively mature outer segments were found only in 2 eyes in which the retinal grafts formed rosettes.

机译：来自正常新生或具有正常视网膜发育的转基因新生小鼠的光感受器被移植到正常大鼠的视网膜下腔。移植后的动物在移植后的前两周接受了他克莫司水合物的免疫抑制治疗或未进行任何治疗。移植后4周，仅在他克莫司治疗的大鼠中发生了移植物存活。在接受治疗的12只眼中，有7只的感光细胞在移植后至少存活了4周。仅在两只视网膜移植物形成玫瑰花结的眼睛中发现了相对成熟的外部节段。

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来源
《Japanese Journal of Ophthalmology》 |1995年第4期|共6页
作者
Yamamoto S; Nagaki Y; Fukuo Y; Hirata H;
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正文语种 eng
中图分类眼科学;
关键词
Immunosuppressive Agents; Photoreceptors; Tacrolimus; Transplantation; Heterologous; 免疫抑制剂; 光感受器; 他罗利姆; 移植; 异种;

机译：Immunosuppressive Agents;Photoreceptors;Tacrolimus;Transplantation;Heterologous;免疫抑制剂;光感受器;他罗利姆;移植;异种;

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专利

1. Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. [J] . Yamamoto S, Nagaki Y, Fukuo Y, Japanese Journal of Ophthalmology . 1995,第4期

机译：水合他克莫司（FK506）处理的光感受器跨物种移植。
2. A long-term comparison of tacrolimus (FK506) versus cyclosporine in liver transplantation: a report of the United States FK506 Study Group. [J] . Wiesner RH Transplantation: Official Journal of the Transplantation Society . 1998,第4期

机译：他克莫司（FK506）与环孢霉素在肝移植中的长期比较：美国FK506研究小组的报告。
3. Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantation. [J] . Eckhoff DE, McGuire BM, Frenette LR, Transplantation: Official Journal of the Transplantation Society . 1998,第2期

机译：他克莫司（FK506）和霉酚酸酯联合治疗与他克莫司在成人肝移植中的治疗。
4. Effect of Intrahepatic Arterial and Intraportal Administration of FK506 on Liver Transplantation Survival for Unresectable Progressive Liver Cancer and Possible Prevention of Tumor Recurrence in Rats [C] . K. Yano, R. Sumimoto, Y. Fukuda, European Society for Surgical Research . 2006

机译：FK506肝内动脉和内部施用对肝移植肝癌肝移植存活的影响及可能预防大鼠肿瘤复发
5. Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Withdrawal Regimens in Patients with Kidney Transplantation: Results from Discrete Event Simulation Modeling. [D] . Desai, Vibha. 2014

机译：基于他克莫司的类固醇激素保留和类固醇戒断方案在肾脏移植患者中的比较有效性：离散事件模拟模型的结果。
6. A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients [O] . Zhengshan Wu, Qingyang Meng, Yongxiang Xia, 2013

机译：回顾性分析低剂量他克莫司（FK506）对活体供肝移植受者的安全性和有效性
7. Does FK506 (Tacrolimus) Induce Hypertrophic Cardiomyopathy? Comparing Echocardiographic Findings of Children on FK506 and Cyclosporine after Orthotopic Liver Transplantation [O] . Ruey-Kang R Chang, Janeth Ceja, Morris Salem, 1999

机译：fk506（tacrolimus）诱发肥厚性心肌病吗？比较儿童儿童的超声心动图在原位肝移植后FK506和环孢菌素
8. Local Tacrolimus (FK506) Delivery for Prevention of Acute Rejection in the Nonhuman Primate Delayed Mixed Chimerism Vascularized Composite Allograft ToleranceInduction Protocol. [R] . Cetrulo, C. L. 2016

机译：局部他克莫司（FK506）用于预防非人灵长类动物延迟混合嵌合血管化复合同种异体移植物耐受诱导方案中的急性排斥反应。

Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment.

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