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首页> 外文期刊>Japanese Journal of Ophthalmology >Higher Concentration of Transforming Growth Factor-beta in Aqueous Humor of Glaucomatous Eyes and Diabetic Eyes.
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Higher Concentration of Transforming Growth Factor-beta in Aqueous Humor of Glaucomatous Eyes and Diabetic Eyes.

机译：在青光眼和糖尿病眼的幽默水中，转化生长因子-β的浓度较高。

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PURPOSE: Diabetic retinopathy and glaucoma are the primary causes of acquired blindness. Cytokines including transforming growth factor (TGF)-beta may be involved in these diseases. We therefore collected aqueous humor samples from patients with glaucoma and/or diabetes who were undergoing surgery, and determined the concentration of TGF-beta.METHODS: Aqueous humor samples were collected from 80 patients (84 eyes), including 19 eyes with primary open-angle glaucoma (POAG), 22 eyes with diabetes, and 18 eyes with diabetes complicated with POAG. Twenty-five eyes with cataract served as controls. The concentration of TGF-beta1 or TGF-beta2 was measured by enzyme-linked immunosorbent assay.RESULTS: The concentration of TGF-beta1 was less than 0.1 pg/mL in all of the groups. In contrast to controls who had 1001.4 +/- 444.1 pg/mL, the concentration of total TGF-beta2 in the diabetes group was 1715.6 +/- 882.1 pg/mL, and that in the diabetes complicated with POAG group was 1692.9 +/- 361.9 pg/mL. These were significantly higher than that in controls. In contrast to the controls who had 321.2 +/- 197.9 pg/mL, the concentration of mature TGF-beta2 with POAG was 822.5 +/- 484.4 pg/mL, and that of diabetes complicated with POAG was 1058.9 +/- 648.4 pg/mL. These were significantly higher than that in the controls. The eyes with diabetes complicated with POAG also had a significantly higher concentration than the eyes with diabetes alone.CONCLUSION: Total TGF-beta2 and mature TGF-beta2 in high concentration may correlate with progression of POAG, diabetes, and diabetes complicated with POAG.
机译：目的：糖尿病性视网膜病变和青光眼是获得性失明的主要原因。包括转化生长因子（TGF）-β在内的细胞因子可能与这些疾病有关。因此，我们从接受手术的青光眼和/或糖尿病患者中收集了房水样本，并确定了TGF-β的浓度。方法：从80例患者（84眼）中收集了房水样本，其中包括19例原发性开放性眼角性青光眼（POAG），22眼糖尿病和18眼糖尿病并发POAG。 25只白内障眼作为对照。通过酶联免疫吸附法测定TGF-β1或TGF-β2的浓度。结果：所有组中TGF-β1的浓度均小于0.1 pg / mL。与对照组的1001.4 +/- 444.1 pg / mL相比，糖尿病组的总TGF-beta2浓度为1715.6 +/- 882.1 pg / mL，而糖尿病合并POAG组的总TGF-beta2浓度为1692.9 +/- 361.9 pg / mL。这些显着高于对照组。与具有321.2 +/- 197.9 pg / mL的对照组相比，POAG的成熟TGF-beta2的浓度为822.5 +/- 484.4 pg / mL，而糖尿病合并POAG的浓度为1058.9 +/- 648.4 pg / mL毫升这些显着高于对照组。结论：合并TAG-β2和成熟TGF-β2的高浓度可能与POAG，糖尿病以及合并POAG的糖尿病的发生有关。

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