首页> 外文期刊>Japanese Journal of Ophthalmology >Intraocular surgery in patients receiving infliximab therapy for Behcet disease.
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Intraocular surgery in patients receiving infliximab therapy for Behcet disease.

机译:接受英夫利昔单抗治疗Behcet病的患者的眼内手术。

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摘要

Infliximab is a humanized antibody against tumor necrosis factor a (TNFa) that can greatly reduce ocular inflammatory attacks in uveitic patients affected by Behcet disease (BD). However, anti-TNFa therapy is also associated with a risk of infectious complications due to the systemic blockade of TNFa. Therefore, intraocular surgery in BD patients under treatment with infliximab may be associated with a higher risk of ocular infections. Moreover, it is unclear if trauma caused by surgery increases disease activity during anti-TNFa treatment. Here, we report the cases of three patients who underwent intraocular surgery while receiving infliximab for BD.
机译:英夫利昔单抗是一种针对肿瘤坏死因子a(TNFa)的人源化抗体,可大大减少受Behcet病(BD)影响的葡萄膜患者的眼部炎症发作。然而,由于TNFα的全身性阻断,抗TNFα疗法也与感染并发症的风险有关。因此,接受英夫利昔单抗治疗的BD患者的眼内手术可能会增加眼部感染的风险。此外,尚不清楚由手术引起的创伤是否会增加抗TNFα治疗期间的疾病活动性。在此,我们报告了三例在接受英夫利昔单抗治疗时接受眼内手术的患者的病例。

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