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首页> 外文期刊>Circulation journal >Low Serum alpha-Tocopherol Concentrations in Subjects With Various Coronary Risk Factors.
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Low Serum alpha-Tocopherol Concentrations in Subjects With Various Coronary Risk Factors.

机译：患有各种冠心病危险因素的受试者的血清α-生育酚浓度低。

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Background Oxidative stress may play an important role in the genesis and development of atherosclerosis. Methods and Results To examine whether oxidative stress is increased in the presence of various coronary risk factors, serum alpha-tocopherol concentrations were determined in 168 apparently healthy subjects recruited from Daioh town (73 men and 95 women, mean age: 42+/-11 years). The alpha-tocopherol concentration (mg/g lipids) was significantly lower in men, older subjects (>/=50 years of age), smokers, those with hyper-low density lipoprotein (LDL)-cholesterolemia (C) (>/=160 mg/dl), hypertriglyceridemia (TG) (>/=150 mg/dl), hypo-high density lipoprotein (HDL)-C (<40 mg/dl), fasting hyperglycemia (>110 mg/dl) and obesity (body mass index >/=25 kg/m (2)) than in women, younger subjects, nonsmokers, those with normoLDL-C, normoTG, normoHDL-C, fasting normoglycemia and the non-obese. The concentration was not significantly different between hypertensives and nonhypertensives. Multivariate logistic regression analysis showed that the adjusted odds ratios (95% confidence interval) for hyperTG and hypoHDL-C as a factor for the lowest tertile of alpha-tocopherol concentration were 6.2 (1.6-24.4, p<0.01) and 6.0 (1.5-22.6, p<0.01), and those of the other risk factors were not significant. The alpha-tocopherol concentrations were significantly positively correlated with HDL-C concentrations (R=0.53) and negatively with TG concentrations (R=-0.53), BMI (R=-0.35), LDL-C concentrations (R=-0.25) and age (R=-0.22). Conclusion Increased oxidative stress, as shown by decreased alpha-tocopherol concentrations, was linked to the presence of various coronary risk factors, among which hyperTG and hypoHDL-C appeared to be most heavily associated with oxidative stress.
机译：背景技术氧化应激可能在动脉粥样硬化的发生和发展中起重要作用。方法和结果为了检查在各种冠心病危险因素存在下氧化应激是否增加，对从Daioh镇招募的168名明显健康的受试者（73名男性和95名女性，平均年龄：42 +/- 11）中的血清α-生育酚浓度进行了测定。年份）。男性，年龄较大的受试者（> / = 50岁），吸烟者，患有超低密度脂蛋白（LDL）-胆固醇血症（C）的人的α-生育酚浓度（mg / g脂质）显着降低。 160 mg / dl），高甘油三酸酯血症（TG）（> / = 150 mg / dl），超高密度脂蛋白（HDL）-C（<40 mg / dl），空腹高血糖症（> 110 mg / dl）和肥胖症（体重指数> / = 25 kg / m（2）），高于女性，较年轻的受试者，非吸烟者，患有normoLDL-C，normoTG，normoHDL-C，禁食常血糖和非肥胖者。高血压和非高血压患者的浓度无明显差异。多元logistic回归分析显示，hyperTG和hypoHDL-C作为α-生育酚浓度最低三分位数的一个因素，校正后的优势比（95％置信区间）为6.2（1.6-24.4，p <0.01）和6.0（1.5- 22.6，p <0.01），其他危险因素均不显着。 α-生育酚浓度与HDL-C浓度呈正相关（R = 0.53），与TG浓度呈负相关（R = -0.53），BMI（R = -0.35），LDL-C浓度（R = -0.25）和年龄（R = -0.22）。结论降低的α-生育酚浓度表明氧化应激的增加与各种冠心病危险因素的存在有关，其中hyperTG和hypoHDL-C似乎与氧化应激最相关。

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