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首页> 外文期刊>Circulation journal >Angioscopic assessment of arterial repair following biodegradable polymer-coated biolimus A9-eluting stent implantation. - Comparison with durable polymer-coated sirolimus-eluting stent-.
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Angioscopic assessment of arterial repair following biodegradable polymer-coated biolimus A9-eluting stent implantation. - Comparison with durable polymer-coated sirolimus-eluting stent-.

机译：可生物降解的聚合物涂层生物胶A9洗脱支架植入后的动脉修复血管造影评估。 -与耐用的聚合物涂层西罗莫司洗脱支架的比较。

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BACKGROUND: Second-generation drug-eluting stents (DES) are expected to show better arterial repair than older DES. We angioscopically compared the biodegradable polymer-coated biolimus A9-eluting stent (BES) and durable polymer-coated sirolimus-eluting stent (SES) to explore differences in arterial repair. METHODS AND RESULTS: Angioscopy was performed 9 +/- 1 months after 15 BES and 16 SES were implanted initially in the native coronary artery. Heterogeneity of neointimal coverage (NIC) as well as the dominant NIC grade was examined. NIC was defined as: grade 0 = fully visible struts; grade 1 = struts bulging into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. Heterogeneity was judged when the NIC grade varied >/= 1. In-stent late loss (0.06 +/- 0.23 vs. 0.07 +/- 0.18 mm, P = 0.80), and dominant NIC grade (1.5 +/- 0.8 vs. 1.3 +/- 0.7, P = 0.45) were similar for BES and SES. Within the stents, NIC was more heterogeneous in SES than in BES (P = 0.035). 80% of BES showed homogeneous NIC, while 56% of SES had heterogeneous NIC. CONCLUSIONS: BES showed limited late loss similar to that for SES. Nonetheless, the NIC with BES was more homogeneous than that with SES. Biodegradable polymer-coated BES may have an advantage in homogeneous NIC.
机译：背景：第二代药物洗脱支架（DES）有望比较老的DES表现出更好的动脉修复。我们通过血管镜比较了可生物降解的聚合物涂层的biolimus A9洗脱支架（BES）和耐用的聚合物涂层的西罗莫司洗脱支架（SES），以探讨动脉修复的差异。方法和结果：最初在天然冠状动脉中植入15 BES和16 SES后9 +/- 1个月进行了血管镜检查。检查了新内膜覆盖（NIC）的异质性以及占主导地位的NIC等级。 NIC定义为：0级=完全可见的支撑; 1级=撑杆鼓入内腔，但被遮盖; 2级=嵌入式但半透明的支撑杆; 3年级=隐形支柱。当NIC等级变化> / = 1时判断异质性。支架内晚期丢失（0.06 +/- 0.23 vs. 0.07 +/- 0.18 mm，P = 0.80）和主要NIC等级（1.5 +/- 0.8vs。 1.3 +/- 0.7，P = 0.45）对于BES和SES相似。在支架内，NIC在SES中的异质性比在BES中的异质性更高（P = 0.035）。 80％的BES显示均匀的NIC，而56％的SES显示异构的NIC。结论：BES显示出与SES相似的有限的晚期丢失。但是，带有BES的NIC比带有SES的NIC更均匀。可生物降解的聚合物涂层BES在均质NIC中可能具有优势。

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