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首页> 外文期刊>Circulation journal >Comparative Effects of Amlodipine Monotherapy and Combination Therapy With Betaxolol on Cardiac Autonomic Nervous Activity and Health-Related Quality of Life in Patients With Poorly Controlled Hypertension
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Comparative Effects of Amlodipine Monotherapy and Combination Therapy With Betaxolol on Cardiac Autonomic Nervous Activity and Health-Related Quality of Life in Patients With Poorly Controlled Hypertension

机译：氨氯地平单药联合贝他洛尔对高血压控制不良患者的自主神经活动和健康相关生活质量的影响

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Background The aim of the study was to evaluate whether the combined treatment of calcium channel blocker, amlodipine and beta-blocker, betaxolol, favorably affects cardiac autonomic nervous activity (CANA) and health-related quality of life (HRQL). Methods and Results A total of 65 patients with a poor blood pressure (BP) control with a low dose amlodipine therapy were randomly assigned to the amlodipine dose-up group (n=21) and betaxolol adding group (n=44). Before and after a 6-month treatment, BP, heart rate variability (HRV), HRQL and blood chemistries were evaluated. Low frequency (LF) spectra/high frequency (HF) spectra and HF/total power spectra (TP) were calculated as indexes of CANA, and HRQL was assessed by the questionnaire sheets. BP was well controlled in all patients of the present study. In the betaxolol adding group, LF/HF decreased (2.1+1.9 to 1.3+-0.9, p<0.05) and HF/TP reciprocally increased (0.41+-0.17 to 0.52+0.18, p<0.05), whereas the amlodipine dose-up group showed no significant changes in the HRV. HRQL was significantly improved in the betaxolol adding group, whereas it remained unchanged in the amlodipine dose-up group. Blood chemistries remained unchanged except for the slightly increased plasma brain natriuretic peptide concentrations in the betaxolol adding group (36+-47 to 62+-62pg/ml, p<0.05). Conclusions Combined treatment of amlodipine and betaxolol appears to be more useful than amlodipine dose-up therapy, because combined treatment improves CANA and HRQL.
机译：背景研究的目的是评估钙通道阻滞剂，氨氯地平和β-受体阻滞剂，紫杉醇的联合治疗是否对心脏自主神经活动（CANA）和健康相关的生活质量（HRQL）产生有利影响。方法和结果将65例低剂量氨氯地平低血压（BP）对照患者随机分为氨氯地平加药组（n = 21）和倍他洛尔加药组（n = 44）。在6个月的治疗前后，对血压，心率变异性（HRV），HRQL和血液化学成分进行了评估。计算低频（LF）频谱/高频（HF）频谱和HF /总功率频谱（TP）作为CANA的指标，并通过调查表评估HRQL。在本研究的所有患者中，血压均得到良好控制。在添加倍他洛尔的组中，LF / HF降低（2.1 + 1.9至1.3 + -0.9，p <0.05），HF / TP相应地升高（0.41 + -0.17至0.52 + 0.18，p <0.05），而氨氯地平的剂量为-向上组显示HRV无明显变化。在加入紫杉醇的组中，HRQL显着改善，而在氨氯地平给药组中，HRQL保持不变。除加入倍他洛尔的血浆血浆脑利钠肽浓度略有增加外，血液化学基本保持不变（36 + -47至62 + -62pg / ml，p <0.05）。结论氨氯地平联合紫杉醇联合治疗比氨氯地平剂量联合治疗更有效，因为联合治疗可改善CANA和HRQL。

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