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首页> 外文期刊>Circulation journal >Incremental Prognostic Value of Cardiac Function Assessed by ECG-Gated Myocardial Perfusion SPECT for the Prediction of Future Acute Coronary Syndrome
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Incremental Prognostic Value of Cardiac Function Assessed by ECG-Gated Myocardial Perfusion SPECT for the Prediction of Future Acute Coronary Syndrome

机译：心电门控心肌灌注SPECT评估心脏功能对预后未来急性冠脉综合征的预后价值

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Background The prognostic value of ECG-gated rest ~(201)Tl/stress ~(99m)Tc-tetrofosmin myocardial perfusion single-photon emission computed tomography for the prediction of acute coronary syndrome (ACS: myocardial infarction (MI) and unstable angina (UA)) and the implications of ejection fraction (EF) has not yet been defined in Japanese.Methods and Results The 1,895 patients were followed up for the occurrence ACS. The mean follow-up interval was 26.9 +- 15.5 months. The 142 patients with revascularization within 60 days were censored. Summed stress score (SSS) and summed difference score (SDS) were calculated. The 19 MI and 29 UA occurred (1.1% and 1.6%, respectively). Univariate Cox analysis showed that hypertension (Wald 5.09, p<0.05), poststress EF (Wald 10.9, p<0.01), SSS (Wald 12.4, p<0.001) and SDS (Wald 18.7, p<0.001) were significant predictors of ACS. Multivariate Cox analysis showed that hypertension (Wald 4.27, p<0.05) and SDS (Wald 8.59, p<0.01) were independent predictors. When multiple clinical risk factors (number of coronary risk factors >= 2), significant ischemia (SDS >= 4) and low EF (EF <45%) were applied to multivariate Cox analysis, the combination of significant ischemia and low EF showed the highest predictive value (Wald 11.9; p<0.001) for future ACS. Conclusion Poststress EF added incremental prognostic value for the prediction of ACS.
机译：背景ECG门控静息〜（201）Tl /应激〜（99m）Tc-四氟fosmin心肌灌注单光子发射计算机断层扫描对预测急性冠状动脉综合征（ACS：心肌梗塞（MI）和不稳定型心绞痛（ UA）和射血分数（EF）的含义尚未在日语中定义。方法和结果对1,895例ACS患者进行了随访。平均随访时间为26.9±15.5个月。 142例患者在60天内进行了血运重建。计算总压力得分（SSS）和总差异得分（SDS）。发生19 MI和29 UA（分别为1.1％和1.6％）。单因素Cox分析显示高血压（Wald 5.09，p <0.05），后应激EF（Wald 10.9，p <0.01），SSS（Wald 12.4，p <0.001）和SDS（Wald 18.7，p <0.001）是ACS的重要预测指标。多元Cox分析显示高血压（Wald 4.27，p <0.05）和SDS（Wald 8.59，p <0.01）是独立的预测因子。当将多种临床危险因素（冠状动脉危险因素的数量> = 2），显着缺血（SDS> = 4）和低EF（EF <45％）应用于多因素Cox分析时，显着缺血和低EF的组合显示未来ACS的最高预测值（Wald 11.9; p <0.001）。结论应激后EF增加了预测ACS的预后价值。

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