Novel in vivo tool to evaluate autophagic activity in the heart.

Yamaguchi O; Otsu K

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Novel in vivo tool to evaluate autophagic activity in the heart.

机译：评估体内自噬活性的新型体内工具。

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Autophagy is highly conserved machinery that plays a critical role in the removal of damaged cytoplasmic proteins and intracellular organelles. Autophagy involves the sequestration of cytoplasmic material by an isolation membrane to form a double-membrane vacuole, the autophagosome. An autophagosome is delivered to the lysosome by fusion to form the autolysosome in which the sequestered material is degraded. The principal role of autophagy is to supply nutrients for survival, but it also has a causative role in cell death. The genetic deletion of autopha-gic genes, such as Atg5 (autophagy-related 5) or Atg7 (autophagy-related 7) accelerates rather than inhibits cell death, which suggests a predominant survival role of autophagy.

机译：自噬是高度保守的机制，在去除受损的细胞质蛋白和细胞内细胞器中起着至关重要的作用。自噬涉及通过隔离膜隔离细胞质物质，以形成双膜液泡，即自噬体。自噬体通过融合被递送至溶酶体以形成其中溶存的物质被降解的自溶酶体。自噬的主要作用是为生存提供营养，但它在细胞死亡中也具有致病作用。自噬基因的基因缺失，例如Atg5（自噬相关5）或Atg7（自噬相关7）加速而不是抑制细胞死亡，这提示自噬起主要的生存作用。

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《Circulation journal》 |2010年第1期|共2页
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Yamaguchi O; Otsu K;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
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Novel in vivo tool to evaluate autophagic activity in the heart.

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