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首页> 外文期刊>Circulation journal >Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography.
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Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography.

机译：西罗莫司洗脱支架的新内膜覆盖范围的长期随访-通过光学相干断层扫描进行评估。

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BACKGROUND: Late stent thrombosis related to delayed neointimal growth is a major concern after drug-eluting stent (DES) implantation. The time course of neointimal growth and risk factors of uncovered stent struts after sirolimus-eluting stent (SES) was studied using optical coherence tomography (OCT). METHODS AND RESULTS: The 60 patients were enrolled and classified into G1 (follow-up period <9 months, n=27), G2 (9-24 months, n=18), and G3 (>25 months, n=15). The time elapsed since SES implantation was associated with a significant increase in mean neointimal area and neointimal thickness, and also with a significant decrease in the number of uncovered stent struts (G1: 14.8%, G2: 11.7%, and G3: 4.1%, P<0.001). However, only 17.6% of implanted SES was completely covered by neointima, even in the G3 period. Small-diameter SES, complex coronary lesions with lipid and calcium content adjacent to stent struts, and diabetes predicted delayed neointimal coverage of SES struts in G1. CONCLUSIONS: Neointima inside SES progressively increases after the routine follow-up period, but only a few SES were completely covered at 3 years after implantation. OCT is a useful modality for assessing neointimal formation after SES implantation, and may give important information about the strategy of antiplatelet therapy after DES implantation.
机译：背景：与药物内膜支架（DES）植入相关的晚期支架内血栓形成与新内膜生长延迟有关是一个主要问题。使用光学相干断层扫描（OCT）研究了西罗莫司洗脱支架（SES）后新内膜生长的时程和未发现的支架撑杆的危险因素。方法与结果：60例患者被分为G1（随访期<9个月，n = 27），G2（9-24个月，n = 18）和G3（> 25个月，n = 15）。 。自SES植入以来经过的时间与平均新内膜面积和新内膜厚度显着增加以及未覆盖的支架撑杆数量显着减少有关（G1：14.8％，G2：11.7％和G3：4.1％， P ＜0.001）。然而，即使在G3期，植入的SES也只有17.6％被新内膜完全覆盖。小直径SES，冠状动脉支架附近有脂质和钙含量高的复杂冠状动脉病变以及糖尿病预示了G1内SES支撑的新内膜覆盖延迟。结论：常规随访期后，SES内部的新内膜逐渐增加，但植入后3年内仅有少数SES被完全覆盖。 OCT是评估SES植入后新内膜形成的有用方式，并且可能提供有关DES植入后抗血小板治疗策略的重要信息。

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