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首页> 外文期刊>Journal de gyne?cologie, obste?trique et biologie de la reproduction. >Prevalence, risk factors, maternal and fetal morbidity and mortality of intrauterine growth restriction and small-for-gestational age [Prévalence, facteurs de risque et morbi-mortalité materno-f?tale des troubles de la croissance f?tale]
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Prevalence, risk factors, maternal and fetal morbidity and mortality of intrauterine growth restriction and small-for-gestational age [Prévalence, facteurs de risque et morbi-mortalité materno-f?tale des troubles de la croissance f?tale]

机译：宫内生长受限和小胎龄的患病率，危险因素，母婴发病率和死亡率[胎儿生长障碍的患病率，危险因素，发病率和死亡率]

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Objectives.- To assess the prevalence of fetal growth restriction (FGR) and small for gestational age (SGA) in France and other populations, the risk factors associated with SGA and its impact on fetal well-being and obstetrical outcome. Methods.- A critical review of studies identified from searches of PubMed and the Cochrane libraries using the following keywords "intra-uterine growth retardation", "intra-uterine growth restriction", "small for gestational age", " epidemiology", "risk factors", "pregnancy outcome", "maternal morbidity", "perinatal death". Results.- Studies of FGR use multiple definitions, both with respect to cutoffs for defining restricted growth as well as growth norms; however the most common definition for epidemiological research was SGA using a birthweight less than the 10th percentile. Following this definition, SGA births accounted for 8.9% of all live births in 2010 in France. Major risk factors identified in the literature were previous SGA birth (4 fold increase in risk) (LE2), diabetes and vascular diseases (5 fold) (LE3), chronic hypertension (2 fold) (LE2), preeclampsia (5 to 12 fold according to severity) (LE2), pregnancy induced hypertension (2 fold) (LE2), smoking (2-3 fold) (LE2), drug and alcohol use (2-4 fold) (LE2), maternal age over 35 (3 fold) (LE2) and ethnic origin (2-3 fold for African-American or Asian origins) (LE2). Other risk factors with adjusted odds ratios around 1.5 were primiparity (LE2), multiple pregnancy (but only starting at 30 weeks of gestation) (LE2), socioeconomic disadvantage (LE2) and body mass index (BMI 18.5 kg/m2) (LE2) SGA is associated with a four-fold increased risk of stillbirth (LE2) as well as higher rates of cesarean and induced labor before 37 weeks. Conclusions FGR is a complication of pregnancy with adverse consequences for fetal wellbeing. Sociodemographic and clinical risk factors can help to identify pregnant women at risk for this complication.
机译：目标：-评估法国和其他人群的胎儿生长受限（FGR）和小胎龄（SGA）的患病率，与SGA相关的危险因素及其对胎儿健康和产科结局的影响。方法。-对使用以下关键词“宫内发育迟缓”，“宫内生长受限”，“胎龄小”，“流行病学”，“风险”从PubMed和Cochrane文库中检索到的研究进行严格审查因素”，“妊娠结局”，“孕产妇发病率”，“围产期死亡”。结果。-对森林遗传资源的研究使用了多种定义，既包括界定受限制的增长的临界值，也包括增长标准。然而，流行病学研究最常见的定义是出生体重小于10％的SGA。按照这个定义，2010年法国的SGA出生占所有活产的8.9％。文献中确定的主要危险因素是先前的SGA出生（危险增加4倍）（LE2），糖尿病和血管疾病（5倍）（LE3），慢性高血压（2倍）（LE2），先兆子痫（5至12倍）根据严重程度）（LE2），妊娠高血压（2倍）（LE2），吸烟（2-3倍）（LE2），药物和酒精使用（2-4倍）（LE2），35岁以上的孕产妇（3 （LE2）和种族血统（非裔或亚洲血统为2-3倍）（LE2）。调整后的优势比约为1.5的其他危险因素是初产（LE2），多次妊娠（但仅在妊娠30周开始）（LE2），社会经济劣势（LE2）和体重指数（BMI <18.5 kg / m2）（LE2） ）SGA与死胎（LE2）的风险增加了四倍有关，在37周之前剖宫产和引产的比例更高。结论FGR是妊娠的并发症，对胎儿健康有不利影响。社会人口统计学和临床​​风险因素可以帮助识别有此并发症风险的孕妇。

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