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首页> 外文期刊>Circulation journal >Torsional mechanics of the left ventricle in patients after surgical repair of tetralogy of fallot.
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Torsional mechanics of the left ventricle in patients after surgical repair of tetralogy of fallot.

机译：手术治疗四联症患者左心室的扭转力学。

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BACKGROUND: This study aimed to test the hypothesis that alteration of left ventricular (LV) torsional mechanics occurs in patients after repair of tetralogy of Fallot (TOF) and is associated with right ventricular (RV) volume overload and changes in LV configuration. METHODS AND RESULTS: Fifty-five TOF patients aged 19.0 +/- 8.1 years and 27 age-matched healthy controls were studied. The LV and RV volumes were measured using 3-dimensional echocardiography while LV geometry was quantified by the diastolic eccentricity index (EI). The LV peak systolic torsion and systolic twisting and diastolic untwisting velocities were determined by speckle tracking. Compared with controls, patients had significantly greater RV end-systolic (P < 0.001) and diastolic (P < 0.001) volumes and LV diastolic EI (P < 0.001). In contrast, LV peak apical rotation (P < 0.001), systolic torsion (P = 0.004), systolic twisting velocity (P = 0.001), and diastolic untwisting velocity (P = 0.001) were lower in patients than in controls. For the whole cohort, RV EDV and LV diastolic EI correlated negatively with peak systolic torsion, systolic twisting velocity, and diastolic untwisting velocity (all P
机译：背景：这项研究旨在检验假说四联征（TOF）修复后患者发生左心室（LV）扭转力学改变的假设，该假说与右心室（RV）容量超负荷和LV构型改变有关。方法和结果：研究了19.0 +/- 8.1岁的55例TOF患者和27例年龄相匹配的健康对照者。使用3维超声心动图测量LV和RV体积，同时通过舒张性离心率指数（EI）量化LV几何形状。 LV峰值收缩扭力和收缩扭曲和舒张解扭速度通过斑点追踪来确定。与对照组相比，患者的RV收缩末期（P <0.001）和舒张期（P <0.001）和LV舒张期EI（P <0.001）明显增加。相比之下，患者的LV峰值顶旋转（P <0.001），收缩期扭转（P = 0.004），收缩期扭转速度（P = 0.001）和舒张期解捻速度（P = 0.001）均低于对照组。在整个队列中，RV EDV和LV舒张期EI与峰值收缩压，收缩扭曲速度和舒张解捻速度呈负相关（所有P≤0.001）。收缩期扭转与舒张期解捻速度密切相关（r = 0.72，P <0.001），而收缩期扭转速度与LV射血分数相关（r = 0.3，P = 0.005）。结论：TOF修复后患者左室扭转力学受损，与右室容积超负荷和左室偏心负相关。

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