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首页> 外文期刊>Circulation journal >Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers.
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Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers.

机译：食用绿茶对慢性吸烟者内皮功能和循环内皮祖细胞的影响。

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BACKGROUND: The present study was designed to investigate the effect and relationship of endothelial function and endothelial progenitor cells (EPCs) by green tea consumption in chronic smokers. The numbers of circulating EPCs have an inverse correlation with chronic smoking and endothelial dysfunction. Green tea catechin improved endothelial dysfunction in chronic smokers. METHOD AND RESULTS: In 20 young healthy smokers, endothelial functions, defined by flow-mediated endothelium dependent vasodilation (FMD) of the brachial artery via ultrasound as well as the number of EPCs isolated from peripheral blood, were determined at baseline and at 2 weeks after green tea consumption (8 g/day). Circulating EPCs were quantified by flow cytometry as CD45lowCD34+KDR2+ cells and by acyl-low-density lipoprotein and fluorescein isotiocyanate-lectin double positive cells after culture for 7 days. Clinical characteristics and laboratory findings were not significantly different between the baseline and at 2 weeks after green tea intake. EPC levels were inversely correlated with the number of cigarettes smoked. Circulating EPCs by flow cytometry (78.6+/-72.6 vs 156.1+/-135.8 /ml, p<0.001) and cultured EPCs (118.2+/-35.7 vs 169.31+/-58.3/10 field, p<0.001) increased rapidly at 2 weeks after green tea consumption. FMD was significantly improved after 2 weeks (7.2+/-2.8 vs 9.3+/-2.4, p<0.001). The FMD correlated with EPC counts (r=0.67, p=0.003) before treatment and after 2 weeks (r=0.60, p=0.013). CONCLUSIONS: A short-term administration of green tea consumption induces a rapid improvement of EPC levels and FMD. Green tea consumption may be effective to prevent future cardiovascular events in chronic smokers.
机译：背景：本研究旨在研究慢性吸烟者饮用绿茶对内皮功能和内皮祖细胞（EPC）的影响及其关系。循环EPC的数量与慢性吸烟和内皮功能障碍呈负相关。绿茶儿茶素改善了慢性吸烟者的内皮功能障碍。方法和结果：在基线和第2周时，测定了20名年轻健康吸烟者的血管内皮功能，这些功能由超声通过肱动脉的流量介导的内皮依赖性血管舒张（FMD）以及从外周血中分离的EPC数量确定食用绿茶（每天8克）后。培养7天后，通过流式细胞术将循环的EPC定量为CD45lowCD34 + KDR2 +细胞，并通过酰基低密度脂蛋白和异硫氰酸荧光素-凝集素双阳性细胞进行定量。基线和摄入绿茶后2周之间的临床特征和实验室检查结果无显着差异。 EPC水平与吸烟量成反比。流式细胞仪检测循环EPCs（78.6 +/- 72.6 vs 156.1 +/- 135.8 / ml，p <0.001）和培养的EPCs（118.2 +/- 35.7 vs 169.31 +/- 58.3 / 10 field，p <0.001）在食用绿茶后2周。 2周后FMD明显改善（7.2 +/- 2.8 vs 9.3 +/- 2.4，p <0.001）。 FMD与治疗前和治疗2周后EPC计数相关（r = 0.67，p = 0.003）（r = 0.60，p = 0.013）。结论：短期服用绿茶可引起EPC水平和FMD的快速改善。食用绿茶可能有效预防慢性吸烟者将来发生心血管事件。

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