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首页> 外文期刊>Circulation journal >Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation
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Coagulation Activity is Increased in the Left Atria of Patients With Paroxysmal Atrial Fibrillation During the Non-Paroxysmal Period Comparison With Chronic Atrial Fibrillation

机译：与阵发性心房颤动相比，阵发性心房颤动在非阵发性心房颤动患者左房的凝血活性增加

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Background: Evaluation of plasma markers of thrombin activity (thrombin-antithrombin III complex: TAT), active fibrinolysis (plasmin-alpha 2-plasmin inhibitor complex: PIC), and platelet activity (platelet factor 4: PF4) is useful for identifying patients with various cardiovascular disorders who are at high risk of thromboembolism. In this study, these markers were investigated in the left atria (LA) of patients with paroxysmal atrial fibrillation (pAF) in the non-paroxysmal period.Methods and Results: Patients with pAF (n=10) and chronic AF (cAF) (n=10) were enrolled. TAT, PIC, and PF4 levels were determined in blood samples obtained from the LA of AF patients before radiofrequency catheter ablation. TAT levels were high in both pAF and cAF patients. PF4 levels were slightly elevated in both groups, but there was no significant difference between the groups. On the other hand, PIC levels in both groups were almost within normal limits, again with no significant difference between groups.Conclusions: Coagulation activity is elevated in the LA of patients with pAF, even in the non-paroxysmal period, so these patients are at high risk of thromboembolism and anticoagulant therapy is indicated.
机译：背景：凝血酶活性（凝血酶-抗凝血酶III复合物：TAT），活性纤维蛋白溶解（纤溶酶-α2-纤溶酶抑制剂复合物：PIC）和血小板活性（血小板因子4：PF4）的血浆标志物评估有助于识别患有以下疾病的患者：高血栓栓塞风险的各种心血管疾病。在这项研究中，对非阵发性阵发性房颤（pAF）患者左心房（LA）进行了这些标记物的研究。方法与结果：pAF（n = 10）和慢性AF（cAF）的患者（ n = 10）被招募。在射频导管消融之前，从房颤患者的洛杉矶获得的血液样本中确定TAT，PIC和PF4的水平。 pAF和cAF患者的TAT水平均很高。两组的PF4水平均略有升高，但两组之间无显着差异。另一方面，两组的PIC水平几乎都在正常范围内，各组之间也无显着差异。结论：即使在非阵发性期，pAF患者的LA凝血活性也升高，因此这些患者处于血栓栓塞的高风险中，并且需要抗凝治疗。

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