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首页> 外文期刊>Circulation journal >Latest management and outcomes of major pulmonary embolism in the cardiovascular disease early transport system: Tokyo CCU Network.
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Latest management and outcomes of major pulmonary embolism in the cardiovascular disease early transport system: Tokyo CCU Network.

机译：心血管疾病早期转运系统中重大肺栓塞的最新治疗方法和结果：Tokyo CCU Network。

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BACKGROUND: Major pulmonary embolism (PE) is a life-threatening disorder associated with high mortality and morbidity. The clinical characteristics and outcomes in major PE managed by a well-organized cardiac care regional urban network and hospitals have not been clarified and were examined in the present study. METHODS AND RESULTS: Data from the Tokyo CCU Network registered cohort in 2005-2006 were analyzed. Among 193 patients with major PE and known severities and outcomes, 42 patients had massive PE, defined as cardiogenic shock or cardiac arrest. The median time from symptom onset to CCU admission was 16.3 h. The in-hospital mortality of the 124 patients who received reperfusion therapy was lower than that of the 69 patients that did not receive reperfusion therapy (11.3% vs 18.8%; P=0.15). In multiple logistic regression analyses after adjusting for advanced age and sex, reperfusion therapy was selected as a significant predictor for in-hospital death (adjusted odds ratio, 0.34; 95%CI, 0.12-0.95; P=0.039), in addition to massive type (adjusted odds ratio, 14.02; 95%CI, 4.71-41.76; P<0.0001). CONCLUSIONS: Early transport and specific reperfusion therapy for major PE were effectively performed by the Tokyo CCU Network, suggesting the efficacy of a specialty management system for major PE.
机译：背景：严重的肺栓塞（PE）是一种威胁生命的疾病，与高死亡率和高发病率有关。由一个组织良好的心脏保健区域城市网络和医院管理的主要PE的临床特征和结局尚未明确，在本研究中进行了检查。方法和结果：分析了东京CCU网络注册队列中2005-2006年的数据。在193例具有严重PE且已知严重程度和预后的患者中，有42例患有大规模PE，定义为心源性休克或心脏骤停。从症状发作到接受CCU的中位时间为16.3小时。 124例接受再灌注治疗的患者的院内死亡率低于69例未接受再灌注治疗的患者（11.3％vs 18.8％; P = 0.15）。在针对高龄和性别进行调整后的多项逻辑回归分析中，除了大量患者外，再灌注治疗还被选为院内死亡的重要预测指标（调整比值比，0.34; 95％CI，0.12-0.95; P = 0.039）。类型（调整后的优势比为14.02; 95％CI为4.71-41.76; P <0.0001）。结论：Tokyo CCU Network有效地对大型PE进行了早期转运和特定的再灌注治疗，这表明大型PE的专业管理系统的功效。

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