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首页> 外文期刊>Journal of AAPOS: The official publication of the American Association for Pediatric Ophthalmology and Strabismus >Treatment of severe amblyopia with weekend atropine: results from 2 randomized clinical trials.
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Treatment of severe amblyopia with weekend atropine: results from 2 randomized clinical trials.

机译：周末阿托品治疗严重弱视：两项随机临床试验的结果。

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PURPOSE: To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age. METHODS: We enrolled children into 2 prospective, randomized multicenter clinical trials of amblyopia therapy. Herein we report the results for severe amblyopia, 20/125 to 20/400. In Trial 1, 60 children 3 to 6 years of age (mean, 4.4 years) were randomized to weekend atropine plus a plano lens or weekend atropine plus full spectacle correction for the sound eye. In Trial 2, 40 children 7 to 12 years of age (mean, 9.3 years) were randomized to weekend atropine or 2 hours of daily patching. The visual acuity outcome was assessed at 18 weeks in Trial 1 and 17 weeks in Trial 2. RESULTS: In Trial 1, visual acuity improved by an average of 4.5 lines in the atropine plus correction group (95% CI, 3.2-5.8 lines) and 5.1 lines in the atropine plus plano lens group (95% CI, 3.7-6.4 lines). In Trial 2, visual acuity improved by an average of 1.5 lines in the atropine group (95% CI, 0.5-2.5 lines) and 1.8 lines in the patching group (95% CI, 1.1-2.6 lines). CONCLUSIONS: Weekend atropine can improve visual acuity in children 3 to 12 years of age with severe amblyopia. Improvement may be greater in younger children.
机译：目的：确定周末阿托品治疗3至12岁儿童斜视，屈光参差或两者兼有的严重弱视的有效性。方法：我们将儿童纳入2项弱视治疗的前瞻性，随机，多中心临床试验中。在此，我们报告严重弱视的结果，即20/125至20/400。在试验1中，将60例3至6岁（平均4.4岁）的儿童随机分为周末阿托品加平透镜或周末阿托品加全镜矫正。在试验2中，将40名7至12岁（平均9.3岁）的儿童随机分配到周末阿托品或每天2小时贴片。在第1次试验的第18周和第2次试验的第17周评估了视力结果。结果：在第1次试验中，阿托品加矫正组的视力平均提高了4.5行（95％CI，3.2-5.8行）和阿托品加平晶状体组中的5.1行（95％CI，3.7-6.4行）。在试验2中，阿托品组的视力平均提高了1.5线（95％CI，0.5-2.5线），贴片组的视力平均提高了1.8线（95％CI，1.1-2.6线）。结论：周末阿托品可改善3至12岁严重弱视儿童的视力。小孩子的进步可能更大。

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