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首页> 外文期刊>Circulation journal >Prognostic impact of ventilatory efficiency in heart disease patients with preserved exercise tolerance.
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Prognostic impact of ventilatory efficiency in heart disease patients with preserved exercise tolerance.

机译：通气效率对保留运动耐量的心脏病患者的预后影响。

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BACKGROUND: The minute ventilation/carbon-dioxide output (VE/VCO2) slope as a marker of cardiac events has been established in patients with severe heart failure, but it is not known whether it is useful for other heart diseases. METHODS AND RESULTS: The present study investigated 215 patients with various heart diseases (age 59+/-11 years; ischemic heart disease, n=89; dilated cardiomyopathy, n=38; valvular disease, n=37; hypertensive heart disease, n=33; others, n=18) who underwent cardiopulmonary exercise testing to determine the VE/VCO(2) slope. Patients were divided into 2 groups according to the VE/VCO2 slope and were followed-up for 3 years. Forty-eight cardiac events (6 deaths, 42 re-hospitalizations) occurred during the observation period. Patients with a VE/VCO2 slope >34 had a significantly higher 3-year cardiac event rate (32.1%) than patients with VE/VCO2 slope <34 (18.9%, p<0.05). When patients were selected with relatively preserved peak oxygen uptake values (>16 ml . kg (-1) . min(-1)),patients with VE/VCO2 slope >34 still demonstrated a significantly higher cardiac event rate than other patients (35.0% vs 13.3%, p<0.01). CONCLUSION: The VE/VCO2 slope may be a prognostic indicator of cardiac events in a heterogeneous group of patients with heart disease, independent of exercise tolerance.
机译：背景：在严重心力衰竭患者中，已经确立了微小通气/二氧化碳输出量（VE / VCO2）斜率作为心脏事件的标志，但尚不清楚它是否可用于其他心脏病。方法和结果：本研究调查了215例各种心脏病（年龄59 +/- 11岁;缺血性心脏病，n = 89;扩张型心肌病，n = 38;瓣膜病，n = 37;高血压心脏病，n） = 33;其他人，n = 18）进行了心肺运动测试以确定VE / VCO（2）斜率。根据VE / VCO2斜率将患者分为2组，并随访3年。在观察期间发生了48次心脏事件（6例死亡，42例再次住院）。 VE / VCO2斜率> 34的患者的3年心脏事件发生率（32.1％）明显高于VE / VCO2斜率<34的患者（18.9％，p <0.05）。当选择相对保留的峰值摄氧量（> 16 ml。kg（-1）.min（-1））的患者时，VE / VCO2斜率> 34的患者仍显示出明显高于其他患者的心脏事件发生率（35.0 ％对13.3％，p <0.01）。结论：VE / VCO2斜率可能是异类心脏病患者心脏事件的预后指标，与运动耐量无关。

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