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首页> 外文期刊>Circulation journal >Pioglitazone Reduces the Necrotic-Core Component inCoronary Plaque in Association With EnhancedPlasma Adiponectin in Patients WithType 2 Diabetes Mellitus
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Pioglitazone Reduces the Necrotic-Core Component inCoronary Plaque in Association With EnhancedPlasma Adiponectin in Patients WithType 2 Diabetes Mellitus

机译：吡格列酮与2型糖尿病患者的血浆脂联素增强相关联，可减少冠状斑块中的坏死核心成分

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Background Pioglitazone has a preventive effect on cardiovascular disease, but its ability to stabilize coronary plaque is unknown.Methods and Results A prospective, randomized trial was conducted in 54 patients with type 2 diabetes and stable angina pectoris, randomly assigned to either a pioglitazone group or control group. Non-culprit, angiograph-ically mild-to-moderate obstructive lesions were examined with virtual histology intravascular ultrasound (VH-IVUS).at coronary intervention and 6 months later. In total, 42 lesions of 22 patients in the pioglitazone group and 44 lesions of 24 patients in the control group were analyzed. After 6 months, patients in the pioglitazone group had significantly improved blood sugar, high-sensitivity C-reactive protein, and plasma adiponectin levels. VH-IVUS analysis revealed that, although the total plaque-to-vessel volume was not changed in either group, the necrotic-core area had significantly decreased in the pioglitazone group (-4.6+-5.9% vs 1.1+-9.3%, P=0.001). There was a significant inverse correlation between the change in plasma adiponectin levels and the change in necrotic-core area (r=-0.46, P<0.0001).
机译：背景吡格列酮对心血管疾病具有预防作用，但其稳定冠状动脉斑块的能力尚不清楚。方法和结果对54例2型糖尿病和稳定型心绞痛患者进行了一项前瞻性随机试验，随机分为吡格列酮组或吡格列酮组。控制组。在冠状动脉介入治疗后及6个月后，通过虚拟组织学血管内超声（VH-IVUS）检查非罪犯，血管造影学上轻至中度的阻塞性病变。总共对吡格列酮组22例患者的42个病灶和对照组24例患者的44个病灶进行了分析。 6个月后，吡格列酮组的患者血糖，高敏C反应蛋白和血浆脂联素水平明显改善。 VH-IVUS分析显示，尽管两组的总斑块-血管体积均未改变，但吡格列酮组的坏死核心面积却明显减少（-4.6 + -5.9％vs 1.1 + -9.3％，P = 0.001）。血浆脂联素水平的变化与坏死核心面积的变化之间存在显着的负相关（r = -0.46，P <0.0001）。

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