Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives.

Wang G; Ella-Menye JR; Sharma V

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Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives.

机译：手性1，3-恶二嗪-2-酮衍生物的合成及抑菌活性。

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We report here the design, synthesis, and antibacterial activities of novel classes of compounds containing chiral 1,3-oxazinan-2-ones and oxazolidinones as the basic core structures. These compounds are tertiary amines containing the core structures and two aryl substituents. Several of these molecules exhibit potent antibacterial activities against the tested Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis. These compounds represent new structure scaffolds and can be further optimized to give new antibacterial agents with structures significantly different from those of existing classes of antibiotics.

机译：我们在这里报告的设计，合成和抗菌活性的新型类化合物包含手性的1，3-恶二嗪-2-酮和恶唑烷酮作为基本的核心结构。这些化合物是含有核心结构和两个芳基取代基的叔胺。这些分子中的几种对测试的革兰氏阳性细菌表现出有效的抗菌活性，包括金黄色葡萄球菌，粪肠球菌和枯草芽孢杆菌。这些化合物代表了新的结构支架，可以进一步优化以提供新的抗菌剂，其结构与现有抗生素类别明显不同。

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《Bioorganic and Medicinal Chemistry Letters》 |2006年第8期|共5页
作者
Wang G; Ella-Menye JR; Sharma V;
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正文语种 eng
中图分类药学;生物化学;
关键词
Anti-Bacterial Agents; Bacillus subtilis; Enterococcus faecalis; Oxazolidinones; 芽孢杆菌; 枯草; 肠球菌; 粪; 葡萄球菌; 金黄色;

机译：Anti-Bacterial Agents;Bacillus subtilis;Enterococcus faecalis;Oxazolidinones;芽孢杆菌;枯草;肠球菌;粪;葡萄球菌;金黄色;

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Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives.

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