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首页> 外文期刊>JAMA otolaryngology-- head & neck surgery >Reliability of a Transnasal Flexible Fiberoptic In-Office Laryngeal Biopsy
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Reliability of a Transnasal Flexible Fiberoptic In-Office Laryngeal Biopsy

机译：经鼻柔性纤维内办公室喉镜活检的可靠性

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Results: Adequate tissue for diagnostic purposes was obtained in 96 of 102 in-office TFL biopsies (94.1%). The biopsy results revealed invasive carcinoma in 34 patients (35.4%), carcinoma in situ in 17 patients (17.7%), and benign lesions in 45 patients (46.9%). All patients with benign lesions and carcinoma in situ were referred for biopsy of samples obtained using direct laryngos-copy, to which 57 patients agreed. The final pathologic results identified from the biopsies on direct laryngos-copy revealed that there was an underestimation of the TFL results in 30 of 91 patients (false-negative rate, 33.0%) and an overestimation in 1 patient (false-positive rate, 1.1%). The sensitivity of TFL biopsy compared with that of direct laryngoscopy biopsy was 69.2% and the specificity was 96.1%. Conclusions and Relevance: Transnasal fiberoptic laryngoscopy yielded low sensitivity in assessing suspicious lesions of the larynx. These results may indicate that direct laryngoscopy represents the definitive pathologic diagnostic procedure whenever the pathologic results of an in-office TFL procedure are interpreted as benign or as carcinoma in situ.
机译：结果：102例办公室TFL活检中有96例获得了足够的用于诊断目的的组织（94.1％）。活检结果显示浸润性癌34例（35.4％），原位癌17例（17.7％），良性病变45例（46.9％）。将所有具有良性病变和原位癌的患者转诊以使用直接喉镜检查获得的样本进行活检，其中57例患者同意。从直接喉镜活检中确定的最终病理结果表明，91例患者中有30例的TFL结果被低估（假阴性率33.0％），而1例患者的TFL结果被高估了（假阳性率1.1％） ％）。与直接喉镜活检相比，TFL活检的敏感性为69.2％，特异性为96.1％。结论和相关性：经鼻纤维喉镜检查在评估喉部可疑病变时敏感性较低。这些结果可能表明，只要办公室TFL手术的病理结果被解释为良性或原位癌，直接喉镜就代表了确定的病理诊断程序。

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