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首页> 外文期刊>JAMA otolaryngology-- head & neck surgery >Treatment of Neural Anosmia by Topical Application of Basic Fibroblast Growth Factor-Gelatin Hydrogel in the Nasal Cavity An Experimental Study in Mice
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Treatment of Neural Anosmia by Topical Application of Basic Fibroblast Growth Factor-Gelatin Hydrogel in the Nasal Cavity An Experimental Study in Mice

机译：碱性成纤维细胞生长因子-明胶水凝胶在鼻腔局部应用治疗神经性贫血的实验研究

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摘要

Importance: A new treatment of neural anosmia.Objective: To investigate the effects of basic fibroblast growth factor (bFGF)-gelatin hydrogel on recovery of neural anosmia in mice.Design: Anosmia was induced by intraperitoneal injection of 3-methylindole, 200 mg/kg. One week later, the animals underwent 1 of the following 3 procedures bilaterally: (1) group A: single-shot intranasal drip infusion of phosphate-buffered saline, (2) group B: single-shot intranasal drip infusion of bFGF, and (3) group C: placement of bFGF-gelatin hydrogel in the nasal cavity. The olfactory function of the animal was evaluated by the odor-detection test (ODT) 2 and 4 weeks later. Following the testing, the animal was killed, the thickness of the olfactory epithelium was measured, and the number of olfactory marker protein (OMP)-positive cells was counted.
机译：重要性：一种新的神经性贫血治疗方法：目的：研究碱性成纤维细胞生长因子（bFGF）-明胶水凝胶对小鼠神经性贫血恢复的影响设计：腹膜内注射3-甲基吲哚200 mg /公斤。一周后，对动物进行以下3种操作之一：（1）A组：鼻腔滴注磷酸盐缓冲液，（2）B组：鼻内滴注bFGF，以及（ 3）C组：将bFGF-明胶水凝胶置于鼻腔中。 2周和4周后通过气味检测试验（ODT）评估动物的嗅觉功能。测试后，杀死动物，测量嗅上皮的厚度，并计算嗅标记蛋白（OMP）阳性细胞的数量。

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