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首页> 外文期刊>JAMA: the Journal of the American Medical Association >Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.
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Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.

机译：怀孕期间补充DHA对幼儿的母亲抑郁和神经发育的影响：一项随机对照试验。

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CONTEXT: Uncertainty about the benefits of dietary docosahexaenoic acid (DHA) for pregnant women and their children exists, despite international recommendations that pregnant women increase their DHA intakes. OBJECTIVE: To determine whether increasing DHA during the last half of pregnancy will result in fewer women with high levels of depressive symptoms and enhance the neurodevelopmental outcome of their children. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, multicenter, randomized controlled trial (DHA to Optimize Mother Infant Outcome [DOMInO] trial) in 5 Australian maternity hospitals of 2399 women who were less than 21 weeks' gestation with singleton pregnancies and who were recruited between October 31, 2005, and January 11, 2008. Follow-up of children (n = 726) was completed December 16, 2009. INTERVENTION: Docosahexaenoic acid-rich fish oil capsules (providing 800 mg/d of DHA) or matched vegetable oil capsules without DHA from study entry to birth. MAIN OUTCOME MEASURES: High levels of depressive symptoms in mothers as indicated by a score of more than 12 on the Edinburgh Postnatal Depression Scale at 6 weeks or 6 months postpartum. Cognitive and language development in children as assessed by the Bayley Scales of Infant and Toddler Development, Third Edition, at 18 months. RESULTS: Of 2399 women enrolled, 96.7% completed the trial. The percentage of women with high levels of depressive symptoms during the first 6 months postpartum did not differ between the DHA and control groups (9.67% vs 11.19%; adjusted relative risk, 0.85; 95% confidence interval [CI], 0.70-1.02; P = .09). Mean cognitive composite scores (adjusted mean difference, 0.01; 95% CI, -1.36 to 1.37; P = .99) and mean language composite scores (adjusted mean difference, -1.42; 95% CI, -3.07 to 0.22; P = .09) of children in the DHA group did not differ from children in the control group. CONCLUSION: The use of DHA-rich fish oil capsules compared with vegetable oil capsules during pregnancy did not result in lower levels of postpartum depression in mothers or improved cognitive and language development in their offspring during early childhood. TRIAL REGISTRATION: anzctr.org.au Identifier: ACTRN12605000569606.
机译：背景：尽管国际上建议孕妇增加DHA摄入量，但饮食中二十二碳六烯酸（DHA）对孕妇及其子女的益处尚不确定。目的：确定在怀孕后半期增加DHA是否会导致患有抑郁症的孕妇人数减少，并增强孩子的神经发育结局。设计，地点和参加者：一项双盲，多中心，随机对照试验（DHA优化母婴结局[DOMInO]试验）在澳大利亚5所妇产医院中，有2399名妇女，其妊娠少于21周且单胎妊娠并且在2005年10月31日至2008年1月11日之间招募了儿童。对儿童（n = 726）的随访于2009年12月16日完成。干预：富含二十二碳六烯酸的鱼油胶囊（提供800 mg / d的DHA）或从研究开始到出生，都匹配无DHA的植物油胶囊。主要观察指标：产后6周或6个月爱丁堡产后抑郁量表的得分超过12分，表明母亲的抑郁症状较高。根据第18版贝利婴儿和幼儿发展量表评估，儿童的认知和语言发展。结果：在2399名妇女中，有96.7％完成了试验。在DHA和对照组之间，产后前6个月中抑郁症状高的女性百分比没有差异（9.67％vs 11.19％;校正后的相对风险为0.85; 95％的置信区间[CI]为0.70-1.02; P = .09）。平均认知综合评分（调整后平均差异，0.01; 95％CI，-1.36至1.37; P = 0.99）和平均语言综合评分（调整后平均差异，-1.42; 95％CI，-3.07至0.22; P = 0。 09）DHA组儿童与对照组儿童无差异。结论：在妊娠期间使用富含DHA的鱼油胶囊与植物油胶囊相比，在母亲早期没有降低母亲的产后抑郁水平或改善其后代的认知和语言发育。试用注册：anzctr.org.au标识符：ACTRN12605000569606。

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