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首页> 外文期刊>Journal of aerosol medicine and pulmonary drug delivery >A computational fluid dynamics model for drug delivery in a nasal cavity with inferior turbinate hypertrophy.
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A computational fluid dynamics model for drug delivery in a nasal cavity with inferior turbinate hypertrophy.

机译：用于鼻甲肥大的鼻腔内药物输送的计算流体动力学模型。

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BACKGROUND: Intranasal medications are commonly used in treating nasal diseases. However, technical details of the correct usage of these medications for nasal cavity with obstruction are unclear. METHODS: A three-dimensional model of nasal cavity was constructed from MRI scans of a healthy human subject. Nasal cavities corresponding to healthy, moderate, and severe nasal obstruction (NO) were simulated by enlarging the inferior turbinate geometrically, which was documented by approximately one-third reduction of the minimum cross-sectional area for the moderate and two-thirds for the severe obstruction. The discrete phase model based on steady-state computational fluid dynamics was used to study the gas-particle flow. The results were presented with drug particle (from 7 x 10 to 10 m) deposition distribution along the lateral walls inside these three nasal cavities, and comparisons of the particle ratio escaping from the cavity were also presented and discussed. RESULTS: Nasal patency is an essential condition that had the most impact on particle deposition of the factors studied; the particle percentage escaping the nasal cavity decreased to less than a half and one-tenth for the moderately and severely blocked noses. Decreasing of flow rate and particle diameter increased the escaping ratio; however, zero escaping percentage was detected with the absence of air flow and the effect was less noticeable when the particle diameter was very small (<10 m). The existence of inspiratory flow and head tilt angle helped to improve the particle escaping ratio for the healthy nose; however, such changes were not significant for the moderately and severely blocked noses. CONCLUSION: When using an intranasal medication, it is advisable to have a moderate inspiratory air-flow rate and small size particles to improve particle escaping ratio. Various head positions suggested by clinicians do not seem to improve the drug escaping ratio significantly for the nasal cavities with inferior turbinate hypertrophy.
机译：背景：鼻内药物通常用于治疗鼻部疾病。但是，对于鼻腔阻塞的药物的正确用法的技术细节尚不清楚。方法：根据健康人的MRI扫描建立鼻腔三维模型。通过扩大下鼻甲的几何形状来模拟对应于健康，中度和重度鼻塞（NO）的鼻腔，这可以通过减少中度最小横截面面积约三分之一，重度减少三分之二来证明。梗阻。基于稳态计算流体动力学的离散相模型用于研究气体颗粒的流动。结果显示了药物颗粒在这三个鼻腔内部沿侧壁的沉积分布（从7 x 10到10 m），并且对从腔中逸出的颗粒比率进行了比较和讨论。结果：鼻腔通畅是研究因素中对颗粒沉积影响最大的必要条件。对于中度和重度阻塞的鼻子，逸出鼻腔的颗粒百分比降低到不到一半和十分之一。流量和粒径的减小增加了逃逸率。但是，在没有气流的情况下，检测到的逸出百分数为零，并且当粒径非常小（<10 m）时，效果不太明显。吸气流量和头部倾斜角度的存在有助于提高健康鼻子的颗粒逃逸率;但是，对于中度和重度阻塞的鼻子，这种变化并不明显。结论：使用鼻内药物时，建议吸气速度适中，小颗粒，以提高颗粒逃逸率。对于鼻甲肥大的鼻腔，临床医生建议的各种头部姿势似乎并未显着改善药物逸出率。

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