...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Analytical Toxicology >Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine.
【24h】

Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine.

机译：评价DRI羟考酮免疫分析法检测尿中的羟考酮。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We evaluated the performance of the DRI Oxycodone (DRI-Oxy) enzyme immunoassay for the detection of oxycodone and its primary metabolite, oxymorphone, in urine, by testing 1523 consecutive urine specimens collected from pain management patients. All 1523 specimens were tested with the DRI-Oxy assay at a cut-off of 100 ng/mL and then analyzed by gas chromatography-mass spectrometry (GC-MS) for opiates, including oxycodone and oxymorphone. Approximately 29% (435) of the 1523 specimens yielded positive results by the DRI-Oxy assay. Of these 435 specimens, GC-MS confirmed the presence of oxycodone and/or oxymorphone at >100 ng/mL in 433 specimens, an agreement of 99.5%. In addition to oxycodone and/or oxymorphone, 189 of the 433 positive specimens contained other opiates including codeine, hydrocodone, hydromorphone, and morphine. These other opiates were also present in 54% (590/1084) of the oxycodone negative specimens. The DRI-Oxy assay demonstrated no cross-reactivity, yielding negative results, with specimens containing concentrations of codeine, >75,000 ng/mL; hydrocodone, >75,000 ng/mL; hydromorphone, >12,000 ng/mL; and morphine, >163,000 ng/mL. From the presented study, the sensitivity of the DRI-Oxy was 0.991 and the selectivity 0.998. The DRI-Oxy assay provided a highly reliable method for the detection of oxycodone and/or oxymorphone in urine specimens.
机译：我们通过测试从疼痛管理患者收集的1523份连续尿液样本，评估了DRI羟考酮（DRI-Oxy）酶免疫测定法在尿液中检测羟考酮及其主要代谢产物羟吗啡酮的性能。所有1523个样品均以100 ng / mL的截断值通过DRI-Oxy分析进行测试，然后通过气相色谱-质谱（GC-MS）分析鸦片剂，包括羟考酮和羟吗啡酮。通过DRI-Oxy分析，在1523个样本中大约有29％（435）产生了阳性结果。在这435个标本中，GC-MS确认了433个标本中> 100 ng / mL的羟考酮和/或羟吗啡酮的存在，一致性为99.5％。除羟考酮和/或羟吗啡酮外，433个阳性标本中的189个还含有其他鸦片制剂，包括可待因，氢可酮，氢吗啡酮和吗啡。这些其他阿片类药物也存在于54％（590/1084）的羟考酮阴性标本中。 DRI-Oxy分析显示无交叉反应，产生阴性结果，样品中可待因的浓度> 75,000 ng / mL;氢可酮，> 75,000 ng / mL;氢吗啡酮，> 12,000 ng / mL;吗啡> 163,000 ng / mL。从提出的研究中，DRI-Oxy的灵敏度为0.991，选择性为0.998。 DRI-Oxy测定法为检测尿液样本中的羟考酮和/或羟吗啡酮提供了高度可靠的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号