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首页> 外文期刊>Journal of Analytical Toxicology >Applications of ion mobility spectrometry (IMS) to the analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate in toxicological matrices.
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Applications of ion mobility spectrometry (IMS) to the analysis of gamma-hydroxybutyrate and gamma-hydroxyvalerate in toxicological matrices.

机译：离子迁移谱（IMS）在毒理学基质中γ-羟基丁酸酯和γ-羟基戊酸酯分析中的应用。

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摘要

The predator drug gamma-hydroxybutyrate (GHB) and its lactone form gamma-butyrolactone (GBL) continue to present significant analytical challenges to forensic toxicologists and chemists. The five-carbon analogue (gamma hydroxyvalerate GHV) and the corresponding lactone GVL) are emerging as substitutes for GHB, adding further complications. Ion mobility spectrometry (IMS) was investigated as a method of screening urine and breath for the presence of these drugs and their degradation products. Sample was introduced into the instrument via a programmable split/splitless injection port with thermal desorption. The injection method in effect replaces problematic solvent extraction methods with a physical extraction, an efficient method in the present case considering the hydrophilic nature of GHB. No chromatography was employed and results were obtained within a few seconds. The negative ion mode showed the greatest sensitivity with detection limits in the low parts-per-million range for GHB and GHV. Because GHB is often delivered in alcoholic beverages, ethanol and acetaldehyde, along with potential interfering compounds methanol, isopropanol, and acetone, were also analyzed. None were found to interfere. The thermally induced ring opening prevented differentiation of GHB and GBL using direct injection/thermal desorption protocol, but IMS does show promise as a rapid, simple, and affordable screening technique for GHB and related compounds.
机译：捕食性药物γ-羟基丁酸酯（GHB）及其内酯形式的γ-丁内酯（GBL）继续对法医毒理学家和化学家提出重大的分析挑战。五碳类似物（γ-羟基戊酸酯GHV和相应的内酯GVL）正在替代GHB，这进一步增加了复杂性。研究了离子迁移谱（IMS），作为筛查尿液和呼吸中这些药物及其降解产物的方法。通过具有热脱附功能的可编程分流/不分流进样口将样品引入仪器。实际上，注射法用物理萃取代替了有问题的溶剂萃取方法，这是考虑到GHB亲水性的一种有效方法。不使用色谱法，并且在几秒钟内获得结果。负离子模式显示出最高的灵敏度，GHB和GHV的检出限在百万分之一的低范围内。由于GHB通常以含酒精的饮料形式提供，因此还分析了乙醇和乙醛，以及潜在的干扰化合物甲醇，异丙醇和丙酮。没有发现干扰。热诱导的开环阻止了使用直接进样/热脱附方案的GHB和GBL的分化，但是IMS确实显示了对GHB和相关化合物进行快速，简单且可负担得起的筛选技术的希望。

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