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首页> 外文期刊>Journal of Analytical Toxicology >The distribution of fluoxetine in human fluids and tissues.
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The distribution of fluoxetine in human fluids and tissues.

机译：氟西汀在人体液体和组织中的分布。

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Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that was introduced in 1986. Certain side effects of this medication-drowsiness, dizziness, abnormal vision, diarrhea, and headache-could affect pilot performance and become a factor in an aviation accident. Our laboratory has determined the distribution of fluoxetine and its desmethyl metabolite, norfluoxetine, in various postmortem tissues and fluids from 10 fatal aviation accident cases. When available, 11 specimen types were analyzed for each case, including blood, urine, vitreous humor, bile, liver, kidney, skeletal muscle, lung, spleen, heart muscle, and brain. Blood fluoxetine concentrations in these 10 cases ranged from 21 to 1480 ng/mL. The distribution coefficients for both fluoxetine and norfluoxetine, expressed as specimen/blood ratios, were determined. The distribution coefficients for fluoxetine were determined to be 0.9 +/- 0.4 for urine, 0.10 +/- 0.03 for vitreous humor, 9 +/- 1 for bile, 38 +/- 10 for liver, 60 +/- 17 for lung, 9 +/- 3 for kidney, 20 +/- 5 for spleen, 2.2 +/- 0.3 for muscle, 15 +/- 3 for brain, and 10 +/- 2 for heart. To our knowledge, this is the first report presenting the distribution of fluoxetine in humans at therapeutic concentrations.
机译：氟西汀是一种选择性的5-羟色胺再摄取抑制剂（SSRI），于1986年推出。这种药物的某些副作用-嗜睡，头晕，视力异常，腹泻和头痛-可能会影响飞行员的表现，并成为航空事故的一个因素。我们的实验室已从10例致命的航空事故案例中确定了氟西汀及其去甲基代谢产物去氟西汀在各种死后组织和体液中的分布。如果可用，将对每种情况分析11种标本类型，包括血液，尿液，玻璃体液，胆汁，肝，肾，骨骼肌，肺，脾，心肌和脑。这10例患者的血氟西汀浓度范围为21至1480 ng / mL。确定了氟西汀和去甲氟西汀的分布系数，以标本/血液比率表示。氟西汀的分布系数确定为：尿液为0.9 +/- 0.4，玻璃体液为0.10 +/- 0.03，胆汁为9 +/- 1，肝为38 +/- 10，肺为60 +/- 17，肾脏9 +/- 3，脾脏20 +/- 5，肌肉2.2 +/- 0.3，大脑15 +/- 3，心脏10 +/- 2。据我们所知，这是第一个报告氟西汀在治疗浓度下在人体中的分布的报告。

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