Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.

McCooeye MA; Ells B; Barnett DA; Purves RW; Guevremont R

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Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.

机译：使用高光谱非对称波形离子淌度质谱（FAIMS）和质谱检测技术对人尿中吗啡和可待因进行定量。

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摘要

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

机译：吗啡和可待因已通过高场非对称波形离子迁移谱法（FAIMS）结合电喷雾电离（ESI）和质谱（MS）检测在人尿基质中进行了鉴定和测量。向氮气载气中添加氦气使ESI-FAIMS-MS仪器测定吗啡和可待因的灵敏度大大提高。人尿中的吗啡检测限为60 ng / mL，可待因检测限为20 ng / mL，分析前未进行样品的任何纯化，衍生化或色谱分离。

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《Journal of Analytical Toxicology》 |2001年第2期|共7页
作者
McCooeye MA; Ells B; Barnett DA; Purves RW; Guevremont R;
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正文语种 eng
中图分类药学;
关键词
Codeine; Morphine; Spectrometry; Mass; Electrospray Ionization methods; 可待因; 吗啡;

机译：Codeine;Morphine;Spectrometry;Mass;Electrospray Ionization methods;可待因;吗啡;

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专利

1. Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. [J] . McCooeye MA, Ells B, Barnett DA, Journal of Analytical Toxicology . 2001,第2期

机译：使用高光谱非对称波形离子淌度质谱（FAIMS）和质谱检测技术对人尿中吗啡和可待因进行定量。
2. High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electrospray ionization tandem mass spectrometry (LOESI-FAIMS-MSMS) multi-component bioanalytical method development, performance evaluation and demonstration [J] . Wu ST, Xia YQ, Jemal M Rapid Communications in Mass Spectrometry: RCM . 2007,第22期

机译：高场非对称波形离子迁移谱法与液相色谱/电喷雾串联质谱法（LOESI-FAIMS-MSMS）的多组分生物分析方法开发，性能评估和论证
3. High-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled with high-resolution electron transfer dissociation mass spectrometry for the analysis of isobaric phosphopeptides [J] . Xuan Y, Creese AJ, Horner JA, Rapid Communications in Mass Spectrometry: RCM . 2009,第13期

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4. Improved SILAC quantitation for large scale proteomic analyses using High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) [C] . Sibylle Pfammatter, Eric Bonneil, Pierre Thibault ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：利用高场非对称波形离子迁移光谱法（FAIMS）改善大规模蛋白质组学分析的氧化硅酸型定量
5. Advances in high field asymmetric ion mobility spectrometry (FAIMS) analyzers and FAIMS-mass spectrometry interfaces [D] . Ridgeway, Mark E., Jr. 2010

机译：高场非对称离子迁移谱仪（FAIMS）分析仪和FAIMS质谱仪接口的进展
6. High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) for Mass Spectrometry-Based Proteomics [O] . Kristian E. Swearingen, Robert L. Moritz -1

机译：基于质谱的蛋白质组学的高场非对称波形离子迁移光谱法（Faims）
7. Quantitation of Morphine and Codeine in Human Urine using High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) with Mass Spectrometric Detection [O] . M. A. McCooeye, B. Ells, D. A. Barnett, 2001

机译：使用质谱检测使用高场非对称波形离子迁移光谱法（FAIMS）定量人类尿液中的尿液中的尿液
8. Characterization Of Commonly Encountered Explosives Using Highfield Asymmetric Waveform Ion Mobility Spectrometry Coupled With Mass Spectrometry [R] . Boock, J. J. 2007

机译：利用高场非对称波形离子迁移谱与质谱联用表征常见爆炸物

Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.

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