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外文期刊>Journal of Analytical Toxicology
>Concentrations of Morphine and Codeine in Paired Oral Fluid and Urine Specimens Following Ingestion of a Poppy Seed Roll and Raw Poppy Seeds
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Concentrations of Morphine and Codeine in Paired Oral Fluid and Urine Specimens Following Ingestion of a Poppy Seed Roll and Raw Poppy Seeds
Interpretation of opiate drug test results can be challenging due to casual dietary consumption of poppy seeds, which may contain variable opiate content. Opiate concentrations in paired oral fluid (OF), collected with the Oral-Eze (R) Oral Fluid Collection System, and urine were analyzed after ingestion of poppy seeds from the same source, consumed raw or contained in a roll. In Part 1, 12 individuals consumed equal portions of a poppy seed roll. For Part 2, the same individuals consumed an equivalent quantity of raw poppy seeds, containing similar to 3.2 mg of morphine and 0.6 mg of codeine. Specimens were analyzed both by enzyme immunoassay (opiates) and by GC-MS (morphine/codeine). Urinary morphine was between 155-1,408 (roll) and 294-4,213 ng/mL (raw), measured at 2, 4, 6 and 20 h post-ingestion. Urinary codeine concentrations between 140-194 (roll) and 121-664 ng/mL (raw) were observed up to 6 h post-ingestion. Following consumption of raw poppy seeds, OF specimens were positive, above LOQ, from 0.25 to 3.0 h with morphine ranging from 7 to 600 ng/mL and codeine from 8 to 112 ng/mL. After poppy seed roll consumption, morphine concentrations of 7-143 ng/mL were observed up to 1.5 h with codeine detected in only 5.5% of OF specimens and ranging from 8 to 28 ng/mL. Combined with the existing poppy seed literature, these results support previous findings and provide guidance for interpretation of OF opiate testing.
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机译：由于罂粟种子的日常饮食消耗可能包含可变的鸦片含量，因此鸦片药物测试结果的解释可能具有挑战性。在从同一来源摄入，食用原料或制成卷装的罂粟种子后，分析了用Oral-Eze（R）口服液收集系统收集的成对口服液（OF）中的鸦片浓度。在第1部分中，有12个人食用了相等数量的罂粟籽卷。对于第2部分，同一个人食用了等量的原始罂粟种子，其中包含约3.2 mg的吗啡和0.6 mg的可待因。通过酶免疫分析（鸦片制剂）和GC-MS（吗啡/可待因）对标本进行分析。尿后吗啡在摄入后2、4、6和20 h测量为155-1408（滚动）至294-4,213 ng / mL（原始）。直至摄入后6小时，尿液中的可待因浓度在140-194（卷）至121-664 ng / mL（原始）之间。食用罂粟种子后，OF样品在LOQ之上为0.25至3.0 h为阳性，其中吗啡为7至600 ng / mL，可待因为8至112 ng / mL。食用罂粟籽卷后，在1.5 h内观察到吗啡浓度为7-143 ng / mL，仅在5.5％的OF标本中检测到可待因，浓度为8至28 ng / mL。结合现有的罂粟种子文献，这些结果支持了先前的发现，并为解释鸦片鸦片检测提供了指导。
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