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首页> 外文期刊>Journal of Analytical Toxicology >Application of the CEDIA 6-MAM assay to routine drugs-of-abuse screening.
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Application of the CEDIA 6-MAM assay to routine drugs-of-abuse screening.

机译：CEDIA 6-MAM分析在常规滥用药物筛选中的应用。

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摘要

A total of 1010 urine specimens obtained from General Practitioners, drug dependency units, and hospitals throughout the West Midlands were screened using the Microgenics CEDIA 6-monoacetylmorphine (6-MAM) assay as a means of establishing its effectiveness as a screening technique to monitor heroin abuse. A total of 282 specimens screened positive for 6-MAM using the CEDIA 6-MAM assay. However, the presence of 6-MAM could not be confirmed by gas chromatography-mass spectrometry in 21 (7%) of the CEDIA-positive specimens. Morphine was identified in all of these specimens at free concentrations ranging between 410 microg/L to 2010 microg/L. The data presented from this preliminary investigation suggests that either there are substances present within the urine specimens, as yet undetermined, which are interfering with the assay or that there may be a greater degree of cross reactivity to other opiates than previously published. 6-MAM assays may be potentially useful rapid screening techniques for high-throughput drugs-of-abuse screening laboratories performing employment and pre-employment screening. However, all positive results will still need to be confirmed by a more sensitive and specific technique.
机译：使用Microgenics CEDIA 6-monoacetylmorphine（6-MAM）分析方法筛选了从全科医生，药物依赖单位和整个西米德兰兹郡的医院获得的1010个尿液标本，以此来确定其作为监测海洛因的筛选技术的有效性滥用。使用CEDIA 6-MAM分析，总共282个样本筛查6-MAM阳性。然而，在21个CEDIA阳性标本中（7％），气相色谱-质谱法无法确定6-MAM的存在。在所有这些标本中都鉴定出吗啡的游离浓度为410 microg / L至2010 microg / L。这项初步研究提供的数据表明，尿液样本中是否存在尚未确定的物质正在干扰测定，或者与以前的鸦片制剂相比，与其他鸦片制剂的交叉反应程度可能更高。对于进行就业和就业前筛查的高通量滥用药物筛查实验室，6-MAM分析可能是有用的快速筛查技术。但是，所有积极的结果仍然需要通过更敏感，更具体的技术来确认。

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